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Exploring vitamin D metabolism and function in cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Sang-Min | - |
dc.contributor.author | Shin, Eun-Ae | - |
dc.date.accessioned | 2024-05-02T06:02:59Z | - |
dc.date.available | 2024-05-02T06:02:59Z | - |
dc.date.created | 2023-04-14 | - |
dc.date.created | 2023-04-14 | - |
dc.date.created | 2023-04-14 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | Experimental & Molecular Medicine, Vol.50 No.4, pp.1-14 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/200568 | - |
dc.description.abstract | Vitamin D, traditionally known as an essential nutrient, is a precursor of a potent steroid hormone that regulates a broad spectrum of physiological processes. In addition to its classical roles in bone metabolism, epidemiological, preclinical, and cellular research during the last decades, it revealed that vitamin D may play a key role in the prevention and treatment of many extra-skeletal diseases such as cancer. Vitamin D, as a prohormone, undergoes two-step metabolism in liver and kidney to produce a biologically active metabolite, calcitriol, which binds to the vitamin D receptor (VDR) for the regulation of expression of diverse genes. In addition, recent studies have revealed that vitamin D can also be metabolized and activated through a CYP11A1-driven non-canonical metabolic pathway. Numerous anticancer properties of vitamin D have been proposed, with diverse effects on cancer development and progression. However, accumulating data suggest that the metabolism and functions of vitamin D are dysregulated in many types of cancer, conferring resistance to the antitumorigenic effects of vitamin D and thereby contributing to the development and progression of cancer. Thus, understanding dysregulated vitamin D metabolism and function in cancer will be critical for the development of promising new strategies for successful vitamin D-based cancer therapy. | - |
dc.language | 영어 | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Exploring vitamin D metabolism and function in cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s12276-018-0038-9 | - |
dc.citation.journaltitle | Experimental & Molecular Medicine | - |
dc.identifier.wosid | 000430144800002 | - |
dc.identifier.scopusid | 2-s2.0-85048945689 | - |
dc.citation.endpage | 14 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1 | - |
dc.citation.volume | 50 | - |
dc.identifier.kciid | ART002342674 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Jeon, Sang-Min | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN COLON-CANCER | - |
dc.subject.keywordPlus | CELL LUNG-CANCER | - |
dc.subject.keywordPlus | ROR-GAMMA EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN-KINASE CK2 | - |
dc.subject.keywordPlus | D-RECEPTOR | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | 1,25-DIHYDROXYVITAMIN D-3 | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | PARATHYROID-HORMONE | - |
dc.subject.keywordPlus | EPIGENETIC REGULATION | - |
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