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mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Soo Seok | - |
dc.contributor.author | Lim, Jaechul | - |
dc.contributor.author | Yu, Zhibin | - |
dc.contributor.author | Kong, Philip | - |
dc.contributor.author | Sefik, Esen | - |
dc.contributor.author | Xu, Hao | - |
dc.contributor.author | Harman, Christian C. D. | - |
dc.contributor.author | Kim, Lark Kyun | - |
dc.contributor.author | Lee, Gap Ryol | - |
dc.contributor.author | Li, Hua-Bing | - |
dc.contributor.author | Flavell, Richard A. | - |
dc.date.accessioned | 2024-05-08T01:57:24Z | - |
dc.date.available | 2024-05-08T01:57:24Z | - |
dc.date.created | 2023-05-03 | - |
dc.date.created | 2023-05-03 | - |
dc.date.created | 2023-05-03 | - |
dc.date.created | 2023-05-03 | - |
dc.date.created | 2023-05-03 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | Science, Vol.367 No.6483, pp.1255-+ | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201128 | - |
dc.description.abstract | T cells maintain a quiescent state prior to activation. As inappropriate T cell activation can cause disease, T cell quiescence must be preserved. Despite its importance, the mechanisms underlying the "quiescent state" remain elusive. Here, we identify BTG1 and BTG2 (BTG1/2) as factors responsible for T cell quiescence. BTG1/2-deficient T cells show an increased proliferation and spontaneous activation due to a global increase in messenger RNA (mRNA) abundance, which reduces the threshold to activation. BTG1/2 deficiency leads to an increase in polyadenylate tail length, resulting in a greater mRNA half-life. Thus, BTG1/2 promote the deadenylation and degradation of mRNA to secure T cell quiescence. Our study reveals a key mechanism underlying T cell quiescence and suggests that low mRNA abundance is a crucial feature for maintaining quiescence. | - |
dc.language | 영어 | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.title | mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/science.aax0194 | - |
dc.citation.journaltitle | Science | - |
dc.identifier.wosid | 000520023800043 | - |
dc.identifier.scopusid | 2-s2.0-85081904519 | - |
dc.citation.endpage | + | - |
dc.citation.number | 6483 | - |
dc.citation.startpage | 1255 | - |
dc.citation.volume | 367 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lim, Jaechul | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | COMPONENT | - |
dc.subject.keywordPlus | HOMOLOG | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | CAF1 | - |
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