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Challenges and opportunities in biopharmaceutical manufacturing control
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Moo Sun | - |
dc.contributor.author | Severson, Kristen A. | - |
dc.contributor.author | Jiang, Mo | - |
dc.contributor.author | Lu, Amos E. | - |
dc.contributor.author | Love, J. Christopher | - |
dc.contributor.author | Braatz, Richard D. | - |
dc.date.accessioned | 2024-05-08T07:29:29Z | - |
dc.date.available | 2024-05-08T07:29:29Z | - |
dc.date.created | 2024-05-08 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | COMPUTERS & CHEMICAL ENGINEERING, Vol.110, pp.106-114 | - |
dc.identifier.issn | 0098-1354 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201237 | - |
dc.description.abstract | This article provides a perspective on control and operations for biopharmaceutical manufacturing. Challenges and opportunities are described for (1) microscale technologies for high-speed continuous processing, (2) plug-and-play modular unit operations with integrated monitoring and control systems, (3) dynamic modeling of unit operations and entire biopharmaceutical manufacturing plants to support process development and plant-wide control, and (4) model-based control technologies for optimizing startup, changeover, and shutdown. A challenge is the ability to simultaneously address the uncertainties, nonlinearities, time delays, non-minimum phase behavior, constraints, spatial distributions, and mixed continuous-discrete operations that arise in biopharmaceutical operations. The design of adaptive and hybrid control strategies is discussed. Process data analytics and grey-box modeling methods are needed to deal with the heterogeneity and tensorial dimensionality of biopharmaceutical data. Novel bioseparations as discussed as a potential cost-effective unit operation, with a discussion of challenges for the widespread application of crystallization to therapeutic proteins. (c) 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Challenges and opportunities in biopharmaceutical manufacturing control | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.compchemeng.2017.12.007 | - |
dc.citation.journaltitle | COMPUTERS & CHEMICAL ENGINEERING | - |
dc.identifier.wosid | 000425114500008 | - |
dc.identifier.scopusid | 2-s2.0-85039761937 | - |
dc.citation.endpage | 114 | - |
dc.citation.startpage | 106 | - |
dc.citation.volume | 110 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Hong, Moo Sun | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANALYTICAL TECHNOLOGY PAT | - |
dc.subject.keywordPlus | POTENTIAL MALARIA VACCINES | - |
dc.subject.keywordPlus | SLUG-FLOW CRYSTALLIZATION | - |
dc.subject.keywordPlus | N-LINKED GLYCOSYLATION | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | PHARMACEUTICAL CRYSTALLIZATION | - |
dc.subject.keywordPlus | MULTIVARIATE-ANALYSIS | - |
dc.subject.keywordPlus | MODEL IDENTIFICATION | - |
dc.subject.keywordPlus | CONTROL STRATEGIES | - |
dc.subject.keywordPlus | SIZE DISTRIBUTION | - |
dc.subject.keywordAuthor | Biopharmaceuticals | - |
dc.subject.keywordAuthor | Biomanufacturing | - |
dc.subject.keywordAuthor | Biopharmaceutical manufacturing | - |
dc.subject.keywordAuthor | Continuous manufacturing | - |
dc.subject.keywordAuthor | Protein crystallization | - |
dc.subject.keywordAuthor | Process data analytics | - |
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