Publications
Detailed Information
Asymmetric Phase-Transfer Catalytic aza-Michael Addition to Cyclic Enone: Highly Enantioselective and Diastereoselective Synthesis of Cyclic 1,3-Aminoalcohols
Cited 4 time in
Web of Science
Cited 4 time in Scopus
- Authors
- Issue Date
- 2022-03
- Publisher
- American Chemical Society
- Citation
- Organic Letters, Vol.24 No.8, pp.1647-1651
- Abstract
- The highly enantioselective aza-Michael reaction of tert-butyl beta-naphthylmetlioxycarbamate to cyclic enones has been accomplished by using a new cinchona alkaloid derived C(9)-urea ammonium catalyst under phase-transfer catalysis conditions with up to 98% ee at 0 degrees C. The resulting aza-Michael adducts can be converted to versatile intermediates by selective deprotection and the cyclic 1,3-aminoalcohols by diastereoselective reduction with up to 32:1, which have been widely used as important pharmacophores in pharmaceutical development.
- ISSN
- 1523-7060
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.