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Iron-Catalyzed Acceptorless Dehydrogenative Coupling of Alcohols With Aromatic Diamines: Selective Synthesis of 1,2-Disubstituted Benzimidazoles
Cited 29 time in
Web of Science
Cited 28 time in Scopus
- Authors
- Issue Date
- 2020-06
- Publisher
- Frontiers Media S.A.
- Citation
- Frontiers in Chemistry, Vol.8, p. 429
- Abstract
- Benzimidazoles are importantN-heteroaromatic compounds with various biological activities and pharmacological applications. Herein, we present the first iron-catalyzed selective synthesis of 1,2-disubstituted benzimidazolesviaacceptorless dehydrogenative coupling of primary alcohols with aromatic diamines. The tricarbonyl (eta(4)-cyclopentadienone) iron complex catalyzed dehydrogenative cyclization, releasing water and hydrogen gas as by-products. The earth abundance and low toxicity of iron metal enable the provision of an eco-friendly and efficient catalytic method for the synthesis of benzimidazoles.
- ISSN
- 2296-2646
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