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Structural Revision of Lydiamycin A by Reinvestigation of the Stereochemistry
Cited 11 time in
Web of Science
Cited 11 time in Scopus
- Authors
- Issue Date
- 2020-05
- Publisher
- American Chemical Society
- Citation
- Organic Letters, Vol.22 No.10, pp.3855-3859
- Abstract
- Lydiamycin A (1) is a previously reported piperazic acid-bearing cyclic peptide from Streptomyces. The absolute configuration of lydiamycin A has not been fully determined despite the fact that multiple total syntheses have been reported. The absolute configuration of 1 was reinvestigated by the advanced Marfey's method, chemical derivatization, and quantum-mechanics-based computational analysis, eventually resulting in a structural revision and establishment of the complete configuration. Lydiamycin A displayed weak antituberculosis activity in vitro.
- ISSN
- 1523-7060
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