Diastereo- and Enantioselective Iridium Catalyzed Carbonyl (alpha-Cyclopropyl)allylation via Transfer Hydrogenation

Abstract

The first examples of diastereo- and enantioselective carbonyl -(cyclopropyl)allylation are reported. Under the conditions of iridium catalyzed transfer hydrogenation using the chiral precatalyst (R)-Ir-I modified by SEGPHOS, carbonyl -(cyclopropyl)allylation may be achieved with equal facility from alcohol or aldehyde oxidation levels. This methodology provides a conduit to hitherto inaccessible inaccessible enantiomerically enriched cyclopropane-containing architectures.