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Efficient enantioselective total synthesis of (-)-horsfiline
Cited 34 time in
Web of Science
Cited 34 time in Scopus
- Authors
- Issue Date
- 2013-07
- Publisher
- John Wiley & Sons Ltd.
- Citation
- Chemistry - A European Journal, Vol.19 No.29, pp.9599-9605
- Abstract
- A new efficient and concise enantioselective synthetic method for (-)-horsfiline is reported. (-)-Horsfiline could be obtained from diphenylmethyl tert-butyl malonate in 9 steps (32%,>99%ee) by using the enantioselective phase-transfer catalytic allylation (91%ee) as the key step. This approach can be applied as a practical route for the large-scale synthesis of spirooxindole natural products, which enables a systematic investigation of their biological activity to be performed.
- ISSN
- 0947-6539
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