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The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion
Cited 30 time in
Web of Science
Cited 34 time in Scopus
- Authors
- Issue Date
- 2013-08
- Publisher
- Elsevier BV
- Citation
- Immunobiology, Vol.218 No.8, pp.1026-1033
- Abstract
- Alloferon is a novel immunomodulatory peptide originally isolated from infected insects. It has antiviral and anti-tumor effects via the activation of NK cells. However, specific mechanisms leading to NK cell activation and anti-tumor responses yet to be clarified. In this study, we demonstrate that alloferon increases killing activity of NK cells to cancer cells via the up-regulation of the expression of NK-activating receptors, 2B4. In addition, the production of IFN-gamma and TNF-alpha and granule exocytosis from NK cells against cancer cell were increased by alloferon. Lastly, the anti-tumor effect of alloferon was confirmed in vivo to demonstrate effective retardation of tumor growth in the human-to-mouse xenograft model. All taken together, these results suggest that alloferon has anti-tumor effects through up-regulation of NK-activating receptor 2B4 and the enhancement of granule exocytosis from NK cells. (C) 2013 Elsevier GmbH. All rights reserved.
- ISSN
- 0171-2985
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