In Vitro Effects of Electromagnetic Field Stimulation on Cells in Tissue Engineering

Abstract

The effects of electromagnetic fields and magnetic fields on cell proliferation is currently an active area of interest. In light of the widespread applications of electromagnetic stimulation for the clinical therapy of periodontal disease, it is likely that electromagnetic stimulation could have an important influence on key functional activities of osteoblasts in alveolar bone. The purpose of our research is to develop an optimized and appropriately characterized non-invasive treatment for alveolar bone tissue engineering using pulsed electromagnetic field stimulation. Based on the reviewed literature, the effects of electromagnetic field stimulation on cells may alter membrane functions such as ion channels, ligand binding, and alterations in the density and distribution of receptors. Each of these mechanisms has the ability to affect transmembrane signaling. Therefore, The oscillating ions during forced-vibration can exert mechanical forces-pressure, on the plasma membrane, capable to upset the membranes electrochemical balance under certain conditions by opening or closing mechanically gated channel proteins like some Ca(2+) influx channels. In light of the widespread applications of electromagnetic fields stimuli for the clinical therapy of periodontal disease, it is likely that electromagnetic fields stimuli could have an important influence on key functional activities of osteoblasts in alveolar bone.