Influence of Static Magnetic Field Stimulation on Cells for Tissue Engineering

Abstract

Stimuli to cells can be grossly classified into chemical and physical stimuli. Magnetic stimulation has been associated with increased collagen deposition, enhanced ion transport, amino acid uptake, fibroblast migration, ATP, and protein synthesis, including a significant increase in the rate of protein and DNA synthesis. Also, theoretical analysis of the effects of applied magnetic fields reveals that activation of transmembrane ion channels by applied fields is likely under certain conditions. Static magnetic fields may have effects on intracellular ion control, especially Ca(2+), as well as mRNA expression, protein synthesis, and gene expression. These magnetic effects on cells show no harmful effect in this weak intensity. Further investigations about interaction of magnetic field and cellular response can help to find a novel method to enhance the proliferation or differentiation of cells.