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ADAR1 and ZBP1 in innate immunity, cell death, and disease
Cited 20 time in
Web of Science
Cited 24 time in Scopus
- Authors
- Issue Date
- 2023-03
- Publisher
- Elsevier BV
- Citation
- Trends in Immunology, Vol.44 No.3, pp.201-216
- Abstract
- ADAR1 and ZBP1 are the only two mammalian proteins that contain Z alpha domains, which are thought to bind to nucleic acids in the Z-conformation. These two mole-cules are crucial in regulating diverse biological processes. While ADAR1-mediated RNA editing supports host survival and development, ZBP1-mediated immune responses provide host defense against infection and disease. Recent studies have expanded our understanding of the functions of ADAR1 and ZBP1 beyond their classical roles and established their fundamental regulation of innate immune responses, including NLRP3 inflammasome activation, inflamma-tion, and cell death. Their roles in these processes have physiological impacts across development, infectious and inflammatory diseases, and cancer. In this re-view, we discuss the functions of ADAR1 and ZBP1 in regulating innate immune responses in development and disease.
- ISSN
- 1471-4906
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