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Metals in Protein-Protein Interfaces
Cited 58 time in
Web of Science
Cited 59 time in Scopus
- Authors
- Issue Date
- 2014
- Publisher
- ANNUAL REVIEWS
- Citation
- ANNUAL REVIEW OF BIOPHYSICS, VOL 43, Vol.43, pp.409-431
- Abstract
- From the catalytic reactions that sustain the global oxygen, nitrogen, and carbon cycles to the stabilization of DNA processing proteins, transition metal ions and metallocofactors play key roles in biology. Although the exquisite interplay between metal ions and protein scaffolds has been studied extensively, the fact that the biological roles of the metals often stem from their placement in the interfaces between proteins and protein subunits is not always recognized. Interfacial metal ions stabilize permanent or transient protein-protein interactions, enable protein complexes involved in cellular signaling to adopt distinct conformations in response to environmental stimuli, and catalyze challenging chemical reactions that are uniquely performed by multisubunit protein complexes. This review provides a structural survey of transition metal ions and metallocofactors found in protein-protein interfaces, along with a series of selected examples that illustrate their diverse biological utility and significance.
- ISSN
- 1936-122X
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