Browse

Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage

Cited 36 time in Web of Science Cited 34 time in Scopus
Authors
Sinn, D. I.; Lee, S. T.; Chu, K.; Jung, K. H.; Song, E. C.; Kim, J. M.; Park, D. K.; Kim, M.; Roh, J. K.
Issue Date
2006-11-25
Publisher
Elsevier
Citation
Neurosci Lett. 2007 Jan 16;411(3):238-42. Epub 2006 Nov 22.
Keywords
AnimalsAntigens, CD11b/metabolismCaspase 3/metabolismCerebral Hemorrhage/chemically induced/*drug therapyCollagenasesDisease Models, AnimalDrug Therapy, CombinationFunctional LateralityIn Situ Nick-End Labeling/methodsMaleMemantine/*therapeutic useNeuroprotective Agents/*therapeutic usePyrazoles/*therapeutic useRatsRats, Sprague-DawleySulfonamides/*therapeutic use
Abstract
Memantine, a N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits hematoma expansion and celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduces perihematomal inflammation in intracerebral hemorrhage. We examined whether the combination treatment has additive effects in experimental intracerebral hemorrhage (ICH). ICH was induced using stereotaxic infusion of collagenase into brains of adult rats. After the induction of ICH, rats were treated with intraperitoneal injection of memantine (20 mg/kg), celecoxib (20 mg/kg) or both agents. Only vehicles were administrated in rats of the control group. Results showed that the combination treatment of memantine and celecoxib reduced both hematoma volume and brain edema. Combination treatment also induced the better functional recovery with further attenuation of cerebral inflammation and apoptosis compared to the control group. When compared to the single agent groups, the combination treatment showed better effects in neuroprotection and anti-inflammation. These results suggest the feasible combined application of memantine and celecoxib in ICH treatment.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0G-4MD9KFJ-7&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7ece4f0ed6d198fbde77e26cfbd83a78

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17123715

http://hdl.handle.net/10371/22329
DOI
https://doi.org/10.1016/j.neulet.2006.10.050
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Neuroscience (뇌신경과학전공)Journal Papers (저널논문_뇌신경과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse