S-Space College of Medicine/School of Medicine (의과대학/대학원) Neuroscience (뇌신경과학전공) Journal Papers (저널논문_뇌신경과학전공)
Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage
- Sinn, D. I.; Lee, S. T.; Chu, K.; Jung, K. H.; Song, E. C.; Kim, J. M.; Park, D. K.; Kim, M.; Roh, J. K.
- Issue Date
- Neurosci Lett. 2007 Jan 16;411(3):238-42. Epub 2006 Nov 22.
- Animals; Antigens, CD11b/metabolism; Caspase 3/metabolism; Cerebral Hemorrhage/chemically induced/*drug therapy; Collagenases; Disease Models, Animal; Drug Therapy, Combination; Functional Laterality; In Situ Nick-End Labeling/methods; Male; Memantine/*therapeutic use; Neuroprotective Agents/*therapeutic use; Pyrazoles/*therapeutic use; Rats; Rats, Sprague-Dawley; Sulfonamides/*therapeutic use
- Memantine, a N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits hematoma expansion and celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduces perihematomal inflammation in intracerebral hemorrhage. We examined whether the combination treatment has additive effects in experimental intracerebral hemorrhage (ICH). ICH was induced using stereotaxic infusion of collagenase into brains of adult rats. After the induction of ICH, rats were treated with intraperitoneal injection of memantine (20 mg/kg), celecoxib (20 mg/kg) or both agents. Only vehicles were administrated in rats of the control group. Results showed that the combination treatment of memantine and celecoxib reduced both hematoma volume and brain edema. Combination treatment also induced the better functional recovery with further attenuation of cerebral inflammation and apoptosis compared to the control group. When compared to the single agent groups, the combination treatment showed better effects in neuroprotection and anti-inflammation. These results suggest the feasible combined application of memantine and celecoxib in ICH treatment.
- 0304-3940 (Print)
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