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Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans
DC Field | Value | Language |
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dc.contributor.author | Koh, Y. Y. | - |
dc.contributor.author | Jung da, E. | - |
dc.contributor.author | Koh, J. Y. | - |
dc.contributor.author | Kim, J. Y. | - |
dc.contributor.author | Yoo, Y. | - |
dc.contributor.author | Kim, C. K. | - |
dc.date.accessioned | 2009-12-24T08:18:32Z | - |
dc.date.available | 2009-12-24T08:18:32Z | - |
dc.date.issued | 2007-05-15 | - |
dc.identifier.citation | Chest. 2007 May;131(5):1454-60. | en |
dc.identifier.issn | 0012-3692 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17494793 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22404 | - |
dc.description.abstract | BACKGROUND: Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles. METHODS: BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8. RESULTS: BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean +/- SD, 418.6 +/- 286.0 pg/mL) compared to the control group (92.8 +/- 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens. CONCLUSION: These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection. | en |
dc.language.iso | en | - |
dc.publisher | American College of Chest Physicians (ACCP) | en |
dc.subject | Antigens, CD3/metabolism | en |
dc.subject | Antigens, CD8/metabolism | en |
dc.subject | Biopsy | en |
dc.subject | Bronchiolitis Obliterans/*etiology/*pathology | en |
dc.subject | Bronchoalveolar Lavage Fluid/*chemistry/*cytology | en |
dc.subject | Bronchoscopy | en |
dc.subject | Case-Control Studies | en |
dc.subject | Cell Count | en |
dc.subject | Child, Preschool | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Interleukin-8/*analysis | en |
dc.subject | Lung/immunology/pathology/radiography | en |
dc.subject | Male | en |
dc.subject | Measles/*complications/*pathology | en |
dc.subject | Neutrophils/pathology | en |
dc.subject | T-Lymphocytes/immunology/pathology | en |
dc.subject | Tomography, X-Ray Computed | en |
dc.title | Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 고영률 | - |
dc.contributor.AlternativeAuthor | 정다은 | - |
dc.contributor.AlternativeAuthor | 고지연 | - |
dc.contributor.AlternativeAuthor | 김정연 | - |
dc.contributor.AlternativeAuthor | 유영 | - |
dc.contributor.AlternativeAuthor | 김창근 | - |
dc.identifier.doi | 10.1378/chest.06-0188 | - |
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