S-Space College of Medicine/School of Medicine (의과대학/대학원) Immunology (면역학전공) Journal Papers (저널논문_면역학전공)
Overexpression of CIITA in T cells aggravates Th2-mediated colitis in mice
- Kim, T. W.; Park, H. J.; Choi, E. Y.; Jung, K. C.
- Issue Date
- Korean Academy of Medical Science
- J Korean Med Sci. 2006 Oct;21(5):877-82.
- Animals; Colitis/*etiology; Interleukin-4/biosynthesis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Proteins/*physiology; Oxazolone/pharmacology; T-Lymphocytes/*metabolism; Th2 Cells/*immunology; Trans-Activators/*physiology
- The MHC class II transactivator (CIITA) is the master transcriptional regulator of genes involved in MHC class II restricted antigen presentation. Previously we suggested another role of CIITA in Th1/Th2 balance by demonstrating that forced expression of CIITA in murine T cells repressed Th1 immunity both in vitro and in vivo. However, the results were contradictory to the report that CIITA functioned to suppress the production of Th2 cytokine by CD4+ T cells in CIITA deficient mice. In this study, we investigated the influence of constitutive expression of CIITA in T cells on Th2 immune response in vivo using murine experimental colitis model. In the dextran sodium sulfate-induced acute colitis, a disease involving innate immunity, CIITA transgenic mice and wild type control mice showed similar progression of the disease. However, the development of oxazolone-induced colitis, a colitis mediated by predominantly Th2 immune response, was aggravated in CIITA-transgenic mice. And, CD4+ T cells from the mesenteric lymph node of CIITA-transgenic mice treated with oxazolone exhibited a high level of IL-4 secretion. Together, these data demonstrate that constitutive expression of CIITA in T cells skews immune response to Th2, resulting in aggravation of Th2-mediated colitis in vivo.
- 1011-8934 (Print)