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Birth month and sensitization to house dust mites in asthmatic children

Cited 11 time in Web of Science Cited 16 time in Scopus
Authors
Yoo, Y.; Yu, J.; Kang, H.; Kim, D. K.; Koh, Y. Y.; Kim, C. K.
Issue Date
2005-09-02
Publisher
Wiley-Blackwell
Citation
Allergy. 2005 Oct;60(10):1327-30.
Keywords
AdolescentAllergens/immunologyAntigens, Dermatophagoides/*immunologyAsthma/*epidemiology/immunologyChildFemaleHumansHypersensitivity, Immediate/*epidemiology/immunologyMalePyroglyphidae/*immunologyRisk FactorsSeasonsSkin Tests
Abstract
BACKGROUND: Early exposure to high quantities of allergen has an important role in the incidence of atopic sensitization. In fact, subjects sensitized to house dust mites (HDMs) have a significantly higher proportion of births in the season when HDMs are most abundant. OBJECTIVE: The aim of this study was to investigate whether birth month patterns differ for asthmatic patients sensitized only to HDMs and for those sensitized to HDMs and other allergen(s). METHODS: Among 2225 patients with asthma, aged 10-16 years, 1642 sensitized to HDMs were identified by skin prick testing. This group was composed of patients sensitized only to HDMs (n = 715) and patients sensitized to HDMs and other allergen(s) (n = 927). The birth month distributions of the group of HDM-sensitive asthmatics or its subgroups were compared with that of a reference population (total live births in the same years as the studied subjects). The risk ratio of a given birth month in relation to all the other months was calculated as an odds ratio (OR) with the corresponding 95% confidence interval (CI). RESULTS: A significant difference in birth month distribution was observed for HDM-sensitive asthmatics (chi(2) = 23.6, P = 0.015), with higher rates of birth in August (OR: 1.23, 95% CI: 1.04-1.46) and September (1.24, 1.04-1.46). When the two subgroups were analyzed separately, significantly more births were noted in August (1.34, 1.06-1.71) and September (1.34, 1.05-1.70) for those sensitized only to HDMs, whereas no such birth month preference was observed for those sensitized to HDMs and other allergen(s). CONCLUSIONS: The HDM-positive asthmatics showed a greater proportion of births in August and September, which correspond to high HDM exposure. However, this birth month pattern was evident in asthmatic-sensitive only to HDMs, but was not observed in those sensitive to HDMs and other allergen(s).
ISSN
0105-4538 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16135003

http://hdl.handle.net/10371/22601
DOI
https://doi.org/10.1111/j.1398-9995.2005.00856.x
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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