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Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphoblastic leukaemia and chronic myelogenous leukaemia in the Korean population

Cited 32 time in Web of Science Cited 35 time in Scopus
Authors
Hur, M.; Park, J. Y.; Cho, H. C.; Lee, K. M.; Shin, H. Y.; Cho, H. I.
Issue Date
2006
Publisher
Wiley-Blackwell
Citation
Clinical and Laboratory Haematology 28, 154-159
Keywords
Child, PreschoolConfidence IntervalsFolic Acid/*metabolismGene Frequency/physiologyHumansInfantKoreaLeukemia, Myelogenous, Chronic, BCR-ABL Positive/enzymology/*geneticsLeukemia, Myeloid, Acute/enzymology/*geneticsMaleMethylenetetrahydrofolate Reductase (NADPH2)/*geneticsMiddle AgedPolymorphism, Genetic/*geneticsPrecursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology/*geneticsRetrospective StudiesRisk Assessment
Abstract
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism, DNA methylation and synthesis. We investigated the association between MTHFR polymorphisms and the risks of acute and chronic leukaemias. MTHFR C677T and A1298C were genotyped in 396 Korean individuals using multiplex polymerase chain reaction/restriction fragment-length polymorphism. They were acute lymphoblastic leukaemia (ALL, n = 89), acute myeloid leukaemia (AML, n = 55), biphenotypic acute leukaemia (n = 12), chronic myelogenous leukaemia (CML, n = 40), and normal controls (n = 200). C677T genotypes were not associated with the risk of each disease. A1298C variants, however, significantly decreased the risks of ALL and CML compared with 1298AA. Odds ratios and 95% confidence intervals of 1298AC and 1298AC + CC were 0.53 (0.31-0.93) and 0.54 (0.31-0.93) in ALL, and 0.34 (0.14-0.80) and 0.40 (0.18-0.89) in CML, respectively, compared with 1298AA. These findings demonstrate that the development of ALL and CML is more dependent on folate status, and more susceptible to DNA instability than that of AML. In addition, A1298C rather than C677T may be a more important genetic risk modifier in leukaemogenesis at least in the Korean population.
ISSN
0141-9854 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16706930

http://hdl.handle.net/10371/23255
DOI
https://doi.org/10.1111/j.1365-2257.2006.00769.x
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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