S-Space College of Medicine/School of Medicine (의과대학/대학원) Program in Clinical Pharmacology (협동과정-임상약리학전공) Journal Papers (저널논문_협동과정-임상약리학전공)
PI3K, RSK, and mTOR signal networks for the GST gene regulation
- Kim, Sang Geon; Lee, Seung Jin
- Issue Date
- Oxford University Press
- Toxicol. Sci. 96, 206-213
- 1-Phosphatidylinositol 3-Kinase/genetics/*metabolism; Animals; Antineoplastic Agents/pharmacology; Antioxidants/pharmacology; Gene Expression Regulation, Enzymologic/drug effects; Glutathione Transferase/genetics/*metabolism; Humans; Protein Kinases/genetics/*metabolism; Ribosomal Protein S6 Kinases; Signal Transduction/drug effects/genetics/*physiology
- The induction of glutathione S-transferases (GST) represents not only cell detoxification and survival but also cancer prevention. In response to various extracellular stimuli, expression of the gene has been shown to be regulated coordinately by activating the transcription factors in a transcriptional or posttranscriptional manner. Cytoprotective agents induce GST and concomitantly activate the PI3K-Akt/ERK-RSK1-mTOR pathways that activate the transcription factors favoring cell viability. The mechanistic basis and cell signaling for the induction of GST induction by prooxidants and toxicants may be different from that by cytoprotective agents. This paper summarizes the molecular mechanisms of the transcriptional induction of the GST gene orchestrated by a series of transcription factors that recruit coactivators or corepressors.
- 1096-6080 (Print)
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