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Association of HLA-DR and -DQ genes with Graves disease in Koreans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Myoung Hee | - |
dc.contributor.author | Park, Young Joo | - |
dc.contributor.author | Song, Eun Young | - |
dc.contributor.author | Park, Hyejin | - |
dc.contributor.author | Kim, Tae Yong | - |
dc.contributor.author | Park, Do Joon | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Cho, Bo Youn | - |
dc.date.accessioned | 2009-12-31T01:16:38Z | - |
dc.date.available | 2009-12-31T01:16:38Z | - |
dc.date.issued | 2005-06-05 | - |
dc.identifier.citation | Hum Immunol. 2005 Jun;66(6):741-7. | en |
dc.identifier.issn | 0198-8859 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15993720 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23868 | - |
dc.description.abstract | Graves disease (GD) is an autoimmune thyroid disease and is associated with human leukocyte antigen (HLA)-DR3 and DQA1*0501 in Caucasians. However, the association of HLA with GD is less clear-cut in East Asian populations. We analyzed HLA-DRB1 and -DQB1 associations with GD in 198 Korean patients compared with 200 healthy controls. HLA-DRB1*0803 (27.8% vs. 14.5% in controls, OR = 2.27, corrected p [p(c)] = 0.03) and *1602 (5.1% vs. 0%, OR = 22.34, p(c) = 0.03) alleles and closely linked haplotypes, DRB1*0803-DQB1*0601 and DRB1*1602-DQB1*0502, conferred susceptibility to GD in Koreans. Weak association of DRB1*0301 with GD susceptibility was observed in male patients only (12.5% vs. 3.5%, OR = 3.57, p < 0.05). HLA-DRB1*0101, *0701, *1202, and *1302 alleles were weakly associated with resistance to the disease (OR < 0.5, p < 0.05). Some HLA alleles were weakly associated with clinical characteristics in GD patients. Patients with DRB1*1301-DQB1*0603 developed their diseases in younger ages and were more frequently associated with larger goiter (p < 0.05). Although HLA class II alleles associated with GD in Koreans were different from those in Caucasians, some associations are shared, such as association of DRB1*0301 in male patients and protective effect of DRB1*0701 to GD susceptibility. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Alleles | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Graves Disease/ethnology/*genetics/physiopathology | en |
dc.subject | HLA-DQ Antigens/*genetics | en |
dc.subject | HLA-DR Antigens/*genetics | en |
dc.subject | Humans | en |
dc.subject | Korea/ethnology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Single-Stranded Conformational | en |
dc.title | Association of HLA-DR and -DQ genes with Graves disease in Koreans | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박명희 | - |
dc.contributor.AlternativeAuthor | 박영주 | - |
dc.contributor.AlternativeAuthor | 송은영 | - |
dc.contributor.AlternativeAuthor | 박혜진 | - |
dc.contributor.AlternativeAuthor | 김태용 | - |
dc.contributor.AlternativeAuthor | 박도준 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 조보연 | - |
dc.identifier.doi | 10.1016/j.humimm.2005.03.001 | - |
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