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The occurrence of cavum septi pellucidi enlargement is increased in bipolar disorder patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Minue J | - |
dc.contributor.author | Lyoo, In Kyoon | - |
dc.contributor.author | Dager, Stephen R | - |
dc.contributor.author | Friedman, Seth D | - |
dc.contributor.author | Chey, Jeanyung | - |
dc.contributor.author | Hwang, Jaeuk | - |
dc.contributor.author | Lee, Yu-Jin | - |
dc.contributor.author | Dunner, David L | - |
dc.contributor.author | Renshaw, Perry F | - |
dc.date.accessioned | 2009-12-31T05:50:40Z | - |
dc.date.available | 2009-12-31T05:50:40Z | - |
dc.date.issued | 2007-04-14 | - |
dc.identifier.citation | Bipolar Disord. 2007 May;9(3):274-80. | en |
dc.identifier.issn | 1398-5647 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17430302 | - |
dc.identifier.uri | https://hdl.handle.net/10371/24526 | - |
dc.description.abstract | OBJECTIVES: This study was conducted to evaluate the prevalence of cavum septi pellucidi (CSP) enlargement in patients with bipolar disorder (BD) and healthy comparison subjects. METHODS: The occurrence of enlarged CSP in patients with BD (n = 41, age 35.4 +/- 10.8 years) and healthy volunteers (n = 41, age 35.3 +/- 10.0 years) was studied using magnetic resonance imaging. The length of the CSP was measured by counting the number of consecutive resliced coronal 0.5-mm images in which the CSP was present. A CSP length > or = 6 mm was a priori defined as abnormal enlargement of the CSP. RESULTS: Bipolar subjects exhibited a significantly higher prevalence of abnormal CSP enlargement (8 of 41 subjects, 19.5%) than healthy comparison subjects (1 of 41 subjects, 2.4%) (logistic regression analysis: Wald statistic = 5.07, df = 1, p = 0.024). The prevalence of abnormally enlarged CSP was not significantly different between drug-naive and drug-exposed bipolar subjects or when comparing bipolar I and II sub-diagnoses. Bipolar subjects with abnormal CSP enlargement had a significantly earlier onset of BD than those without (14.3 +/- 3.6 versus 20.1 +/- 7.4 years, respectively). CONCLUSIONS: The current study is the first to report an increased prevalence of abnormally enlarged CSP in a well-characterized bipolar population. Our finding that an abnormal enlargement of CSP, a neurodevelopmental abnormality, is associated with early onset of illness implicates early maturational processes as contributing to BD. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Bipolar Disorder/*epidemiology/*pathology | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Magnetic Resonance Imaging/*statistics & numerical data | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Prevalence | en |
dc.subject | Septum Pellucidum/*pathology | en |
dc.title | The occurrence of cavum septi pellucidi enlargement is increased in bipolar disorder patients | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 류인균 | - |
dc.contributor.AlternativeAuthor | 최진영 | - |
dc.contributor.AlternativeAuthor | 황재욱 | - |
dc.contributor.AlternativeAuthor | 이유진 | - |
dc.identifier.doi | 10.1111/j.1399-5618.2007.00442.x | - |
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