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Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease
DC Field | Value | Language |
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dc.contributor.author | Nam, Su Y | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Kim, Joo S | - |
dc.contributor.author | Lim, Sun H | - |
dc.contributor.author | Jung, Hyun C | - |
dc.contributor.author | Song, In S | - |
dc.date.accessioned | 2009-12-31T05:55:10Z | - |
dc.date.available | 2009-12-31T05:55:10Z | - |
dc.date.issued | 2007-05-30 | - |
dc.identifier.citation | J Gastroenterol Hepatol. 2007 Jul;22(7):1032-8. Epub 2007 May 27. | en |
dc.identifier.issn | 0815-9319 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17532782 | - |
dc.identifier.uri | https://hdl.handle.net/10371/24529 | - |
dc.description.abstract | BACKGROUND AND AIM: A single nucleotide polymorphism in heat shock protein 70-2 (HSP70-2) has been shown to be associated with a severe clinical course in Crohn's disease (CD), but it is not known if such a relationship exists in ulcerative colitis (UC). The aim of the present study was to identify associations between the HSP70-2 polymorphism and the clinical courses of CD and UC in Koreans. METHODS: Restriction fragment length polymorphism analysis was performed for HSP70-2 polymorphisms using the PstI-cleavage site present in the B allele but not in the A allele of the DNA obtained from 101 patients with CD, 144 patients with UC, and 245 age- and sex-matched healthy controls. Study subjects were classified by disease behavior, severity and extent of disease. RESULTS: In CD, multivariate analysis showed that the AA genotype of HSP70-2 polymorphisms was associated with non-perforating disease (OR 10.10, 95% CI 1.66-15.38) and male sex (OR 3.56, 95% CI 1.04-12.23), and that the BB genotype was associated with severe CD (OR 12.03, 95% CI 1.60-101.56). In contrast, multivariate analysis for UC showed that the AA genotype was associated with severe UC (OR 2.02, 95% CI 1.34-3.03). CONCLUSIONS: CD patients with BB genotype of HSP70-2 polymorphism tend to experience a more severe clinical course and allele A is associated with more severe UC. HSP70-2 polymorphism may be used to predict CD and UC phenotypes, which can illuminate immunological differences in CD and UC. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adult | en |
dc.subject | Colitis, Ulcerative/*genetics | en |
dc.subject | Crohn Disease/*genetics | en |
dc.subject | Female | en |
dc.subject | HSP70 Heat-Shock Proteins/*genetics | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Phenotype | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1440-1746.2007.04927.x | - |
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