Publications
Detailed Information
Association of estrogen receptor alpha gene microsatellite polymorphism with annual changes in bone mineral density in Korean women with hormone replacement therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yim, Chang Hoon | - |
dc.contributor.author | Choi, Jong Tae | - |
dc.contributor.author | Choi, Hyun Ah | - |
dc.contributor.author | Kang, Young Soon | - |
dc.contributor.author | Moon, In Gul | - |
dc.contributor.author | Yoon, Hyun Koo | - |
dc.contributor.author | Han, In Kwon | - |
dc.contributor.author | Kang, Dae Hee | - |
dc.contributor.author | Han, Ki Ok | - |
dc.date.accessioned | 2009-12-31T07:35:39Z | - |
dc.date.available | 2009-12-31T07:35:39Z | - |
dc.date.issued | 2005-09-01 | - |
dc.identifier.citation | J Bone Miner Metab. 2005;23(5):395-400. | en |
dc.identifier.issn | 0914-8779 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16133690 | - |
dc.identifier.uri | https://hdl.handle.net/10371/24595 | - |
dc.description.abstract | Variation in drug response to hormone replacement therapy (HRT) may reflect genetic heterogeneity in the estrogen-related genes, possibly including estrogen receptor alpha (ERalpha) gene. However, only a few association studies of the drug response to HRT have been reported, focusing mainly on the intronic polymorphisms of the ERalpha gene. We therefore examined 284 postmenopausal women (mean age, 52.2 +/- 5.0 years) for the microsatellite thymine-adenine (TA) repeat polymorphism in the promoter of the ERalpha gene and its relationship to drug response by measuring changes in bone mineral density (BMD) after 1 year of HRT. In our study population, the most common number of TA repeats was 14, with a range of values between 11 and 27. At baseline, the number of TA repeats was neither associated with measured lumbar spine or femoral neck BMD nor with bone markers. When we categorized the subjects by the TA repeat numbers into an L group (n = 142), with a low mean number of repeats (TA < 16), and an H group (n = 142), with a high mean number of repeats (TA > or = 16), no significant genotypic differences were noted in spinal or femoral neck BMD or in bone markers. However, the drug response on lumbar spine BMD after 1 year of HRT correlated with the mean number of TA repeats (r = -0.131, P = 0.035) after adjustment for confounding factors such as body mass index and years since menopause. This correlation was also seen with the number of TA repeats on the shorter allele (r = -0.159, P = 0.012), which was defined as the allele with the lower number of TA repeats. However, this genotypic association was not found in the femoral neck BMD (r = 0.053, P = 0.396). When we defined the nonresponder group as women who had lost BMD even with HRT, 15.9% of the subjects were included, and this group was significantly younger and had higher initial BMD than the responder group. After further adjustment for age and initial BMD, the number of TA repeats on the shorter allele remained significantly associated with drug responsiveness (P = 0.005). These data indicate significant effects of the ERalpha TA repeat polymorphism on the estrogen responsiveness of lumbar spine BMD after 1 year of HRT in Korean women. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Alleles | en |
dc.subject | Bone Density | en |
dc.subject | Bone and Bones | en |
dc.subject | DNA/metabolism | en |
dc.subject | Estrogen Receptor alpha/*genetics/metabolism | en |
dc.subject | Female | en |
dc.subject | Femur Neck/pathology | en |
dc.subject | Genotype | en |
dc.subject | Hip/pathology | en |
dc.subject | Hormone Replacement Therapy | en |
dc.subject | Humans | en |
dc.subject | Introns | en |
dc.subject | Korea | en |
dc.subject | Lumbar Vertebrae/metabolism | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Osteoporosis, Postmenopausal/genetics | en |
dc.subject | Microsatellite Repeats | - |
dc.subject | Polymorphism, Genetic | - |
dc.title | Association of estrogen receptor alpha gene microsatellite polymorphism with annual changes in bone mineral density in Korean women with hormone replacement therapy | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 임창훈 | - |
dc.contributor.AlternativeAuthor | 최종태 | - |
dc.contributor.AlternativeAuthor | 최현아 | - |
dc.contributor.AlternativeAuthor | 강영순 | - |
dc.contributor.AlternativeAuthor | 문인걸 | - |
dc.contributor.AlternativeAuthor | 윤현구 | - |
dc.contributor.AlternativeAuthor | 한인권 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.contributor.AlternativeAuthor | 한기옥 | - |
dc.identifier.doi | 10.1007/s00774-005-0619-2 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.