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Effect of genetic polymorphisms of MnSOD and MPO on the relationship between PAH exposure and oxidative DNA damage

Cited 16 time in Web of Science Cited 18 time in Scopus
Authors
Park, So-Yeon; Lee, Kyoung-Ho; Kang, Daehee; Ha, Eun-Hee; Hong, Yun-Chul; Lee, Kwan-Hee
Issue Date
2006
Publisher
Elsevier
Citation
Mutat. Res. 593 (2006) 108-115
Keywords
Base Sequence*DNA DamageDNA PrimersHumans*Oxidative StressPeroxidase/*geneticsPolycyclic Compounds/*toxicity*Polymorphism, GeneticQuestionnairesSuperoxide Dismutase/*genetics
Abstract
To investigate the effect of genetic polymorphisms on the oxidative damage caused by PAH exposure, we measured urinary 1-hydroxypyrene (1-OHP) and 8-hydroxydeoxyguanosine (8-OHdG) levels to determine exposure and oxidative injury in university students. After examining myeloperoxidase (MPO) and manganese superoxide dismutase (MnSOD) genotypes by PCR and RFLP, we evaluated the effects of these polymorphisms on the relationship between the urinary levels of 1-OHP and 8-OHdG. No significant relation was observed between log 1-OHP and 8-OHdG concentrations in the whole study group (p=0.182), or between urinary 8-OHdG levels and polymorphisms of MnSOD or MPO (p=0.539 and 0.993, respectively). However, significant differences of regression coefficient were found for the relation between urinary log 1-OHP and urinary 8-OHdG concentrations in the presence of different MnSOD or MPO genotypes by multiple regression after controlling for age, sex, body mass index, cotinine, and smoking. In those with the MnSOD Val/Ala or Ala/Ala genotypes this regression coefficient was 1.480 (p=0.040), whereas for the MnSOD Val/Val genotype it was 0.088 (p=0.859). The higher regression coefficient was obtained for the subject group with the MnSOD Val/Ala or Ala/Ala genotype in combination with the MPO G/G genotype (p=0.012). We suggest that the oxidative injury caused by PAH exposure is modulated by genetic polymorphisms such as MnSOD and MPO.
ISSN
0027-5107 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16084535

http://hdl.handle.net/10371/24800
DOI
https://doi.org/10.1016/j.mrfmmm.2005.06.022
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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