Browse

Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction

DC Field Value Language
dc.contributor.authorKang, Won Jun-
dc.contributor.authorKang, Hyun-Jae-
dc.contributor.authorKim, Hyo-Soo-
dc.contributor.authorChung, June-Key-
dc.contributor.authorLee, Myung Chul-
dc.contributor.authorLee, Dong Soo-
dc.date.accessioned2010-01-04T04:16:44Z-
dc.date.available2010-01-04T04:16:44Z-
dc.date.issued2006-08-03-
dc.identifier.citationJ Nucl Med. 2006;47:1295-1301en
dc.identifier.issn0161-5505 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16883008-
dc.identifier.urihttp://hdl.handle.net/10371/24824-
dc.description.abstractAdult stem cell therapy is expected to improve left ventricular function in patients with myocardial infarction. Because of the low risk of arrhythmia and the maximal concentration at the target tissue, intracoronary infusion of stem cells is preferred. The aim of this study was to investigate the homing and tissue distribution of intracoronary injected peripheral hematopoietic stem cells labeled with 18F-FDG. METHODS: Seventeen patients with myocardial infarction were included as the intracoronary injection group (14 males, 3 females; age, 58 +/- 12 y). Three patients underwent intravenous stem cell injection as the intravenous injection group (3 males, 0 females; age, 50 +/- 20 y). After mobilization with granulocyte colony-stimulating factor (G-CSF), peripheral stem cells were collected by means of apheresis. 18F-FDG labeling of stem cells was performed for 40 min with gentle intermittent mixing at 37 degrees C. The mean labeling efficiency was 72% (range, 46%-95%), and 44.4-175 MBq (1.2-5 mCi) of 18F-FDG-labeled stem cells were injected via an intracoronary catheter after stenting in infarct-related arteries. PET/CT images were obtained with a 3-dimensional acquisition mode 2 h after intracoronary infusion. RESULTS: Two hours after intracoronary infusion, 1.5% (range, 0.2%-3.3%) of injected stem cells accumulated at the infarcted myocardium. Outside of the myocardium, spleen, liver, bladder, and bone marrow showed a high stem cell accumulation. The delayed image of a patient up to 20 h showed a prolonged residence of stem cells at the myocardium. Intravenous injection of stem cells showed a high initial lung uptake with no myocardial activity. CONCLUSION: We have shown that 18F-FDG-labeled stem cell PET could be used to assess the tissue distribution and to measure the amount of stem cells at a target tissue. 18F-FDG-labeled stem cell PET can be used to measure and optimize the amount of stem cells injected.en
dc.language.isoenen
dc.publisherThe Society of Nuclear Medicine Incen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCoronary Vessels/drug effectsen
dc.subjectFemaleen
dc.subjectFluorodeoxyglucose F18/*diagnostic use/*pharmacokineticsen
dc.subjectGranulocyte Colony-Stimulating Factor/therapeutic useen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyocardial Infarction/*therapyen
dc.subjectPositron-Emission Tomography/methodsen
dc.subjectRadiopharmaceuticals/therapeutic useen
dc.subjectStem Cells/cytology/metabolismen
dc.subjectTissue Distributionen
dc.subjectTomography, X-Ray Computed/methodsen
dc.titleTissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarctionen
dc.typeArticleen
dc.contributor.AlternativeAuthor강원준-
dc.contributor.AlternativeAuthor강현재-
dc.contributor.AlternativeAuthor김효수-
dc.contributor.AlternativeAuthor정준기-
dc.contributor.AlternativeAuthor이명철-
dc.contributor.AlternativeAuthor이동수-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse