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HDAC10 promoter polymorphism associated with development of HCC among chronic HBV patients

Cited 28 time in Web of Science Cited 28 time in Scopus
Authors
Park, Byung Lae; Kim, Yoon Jun; Cheong, Hyun Sub; Lee, Soo Ok; Han, Chang Soo; Yoon, Jung-Hwan; Park, Ju Hyun; Chang, Hun Soo; Park, Choon-Sik; Lee, Hyo-Suk; Shin, Hyoung Doo
Issue Date
2007
Publisher
Elsevier
Citation
Biochem. Biophys. Res. Commun. 363 (2007) 776-781
Keywords
Carcinoma, Hepatocellular/etiology/*geneticsCell Line, TumorDNA Mutational Analysis/statistics & numerical dataGene FrequencyGenotypeHaplotypesHepatitis B virusHepatitis B, Chronic/*complications/virologyHistone Deacetylases/*geneticsHumansKaplan-Meiers EstimateLiver Neoplasms/etiology/*geneticsLuciferases/genetics/metabolism*Polymorphism, Single NucleotidePromoter Regions, Genetic/*geneticsProportional Hazards ModelsRecombinant Fusion Proteins/genetics/metabolismTransfection
Abstract
Histone deacetylases (HDACs) are key enzymes responsible for the removal of acetyl groups from acetylated histone and non-histone proteins, and play important roles in various biological processes including transcription regulation and DNA repair. In this study, we identified 22 sequence variants by direct DNA sequencing in 24 individuals and five common variant were selected for genotyping in larger-scale subjects (n=1095). Statistical analysis revealed that HDAC10-589C>T was significantly associated with HCC occurrence among chronic HBV patients (OR=2.39, P(cor)=0.04) as well as HCC acceleration among chronic HBV patients (RH=1.97, Pcor=0.002). Functional assay also revealed that luciferase activity of "T" allele was significantly higher than that of "C" allele of HDAC10-589C>T (P=0.023). These results suggest that the "T" allele of HDAC10-589C>T affect on the increased transcription activity, and might accelerate HCC development through increased expression of HDAC10.
ISSN
0006-291X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17892858

http://hdl.handle.net/10371/24900
DOI
https://doi.org/10.1016/j.bbrc.2007.09.026
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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