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HDAC10 promoter polymorphism associated with development of HCC among chronic HBV patients
Cited 30 time in
Web of Science
Cited 31 time in Scopus
- Authors
- Issue Date
- 2007
- Publisher
- Elsevier
- Citation
- Biochem. Biophys. Res. Commun. 363 (2007) 776-781
- Keywords
- Carcinoma, Hepatocellular/etiology/*genetics ; Cell Line, Tumor ; DNA Mutational Analysis/statistics & numerical data ; Gene Frequency ; Genotype ; Haplotypes ; Hepatitis B virus ; Hepatitis B, Chronic/*complications/virology ; Histone Deacetylases/*genetics ; Humans ; Kaplan-Meiers Estimate ; Liver Neoplasms/etiology/*genetics ; Luciferases/genetics/metabolism ; Promoter Regions, Genetic/*genetics ; Proportional Hazards Models ; Recombinant Fusion Proteins/genetics/metabolism ; Transfection ; Polymorphism, Single Nucleotide
- Abstract
- Histone deacetylases (HDACs) are key enzymes responsible for the removal of acetyl groups from acetylated histone and non-histone proteins, and play important roles in various biological processes including transcription regulation and DNA repair. In this study, we identified 22 sequence variants by direct DNA sequencing in 24 individuals and five common variant were selected for genotyping in larger-scale subjects (n=1095). Statistical analysis revealed that HDAC10-589C>T was significantly associated with HCC occurrence among chronic HBV patients (OR=2.39, P(cor)=0.04) as well as HCC acceleration among chronic HBV patients (RH=1.97, Pcor=0.002). Functional assay also revealed that luciferase activity of "T" allele was significantly higher than that of "C" allele of HDAC10-589C>T (P=0.023). These results suggest that the "T" allele of HDAC10-589C>T affect on the increased transcription activity, and might accelerate HCC development through increased expression of HDAC10.
- ISSN
- 0006-291X (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17892858
https://hdl.handle.net/10371/24900
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