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Increased GABA levels in medial prefrontal cortex of young adults with narcolepsy

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Authors
Kim, Seog Ju; Lyoo, In Kyoon; Lee, Yujin S; Sung, Young Hoon; Kim, Hengjun J; Kim, Jihyun H; Kim, Kye Hyun; Jeong, Do-Un
Issue Date
2008
Publisher
American Academy of Sleep Medicine
Citation
Sleep 2008;31:342-7
Keywords
AdultBasal Ganglia/physiopathologyCataplexy/diagnosis/genetics/physiopathologyFemaleGenotypeGlutamic Acid/metabolismHLA-DQ Antigens/geneticsHumans*Magnetic Resonance Imaging*Magnetic Resonance SpectroscopyMaleMembrane Glycoproteins/geneticsNarcolepsy/diagnosis/genetics/*physiopathologyPrefrontal Cortex/*physiopathologyReference ValuesSleep Disorders, Circadian Rhythm/diagnosis/genetics/physiopathologygamma-Aminobutyric Acid/*metabolism
Abstract
STUDY OBJECTIVES: To explore absolute concentrations of brain metabolites including gamma amino-butyric acid (GABA) in the medial prefrontal cortex and basal ganglia of young adults with narcolepsy. DESIGN: Proton magnetic resonance (MR) spectroscopy centered on the medial prefrontal cortex and the basal ganglia was acquired. The absolute concentrations of brain metabolites including GABA and glutamate were assessed and compared between narcoleptic patients and healthy comparison subjects. SETTING: Sleep and Chronobiology Center at Seoul National University Hospital; A high strength 3.0 Tesla MR scanner in the Department of Radiology at Seoul National University Hospital. PATIENTS OR PARTICIPANTS: Seventeen young adults with a sole diagnosis of HLA DQB1 0602 positive narcolepsy with cataplexy (25.1 +/- 4.6 years old) and 17 healthy comparison subjects (26.8 +/- 4.8 years old). INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Relative to comparison subjects, narcoleptic patients had higher GABA concentration in the medial prefrontal cortex (t = 4.10, P <0.001). Narcoleptic patients with nocturnal sleep disturbance had higher GABA concentration in the medial prefrontal cortex than those without nocturnal sleep disturbance (t = 2.45, P = 0.03), but had lower GABA concentration than comparison subjects (t = 2.30, P = 0.03). CONCLUSIONS: The current study reports that young adults with narcolepsy had a higher GABA concentration in the medial prefrontal cortex, which was more prominent in patients without nocturnal sleep disturbance. Our findings suggest that the medial prefrontal GABA level may be increased in narcolepsy, and the increased medial prefrontal GABA might be a compensatory mechanism to reduce nocturnal sleep disturbances in narcolepsy.
ISSN
0161-8105 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18363310

http://hdl.handle.net/10371/24906
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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