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Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yun-Sang | - |
dc.contributor.author | Jeong, Jae Min | - |
dc.contributor.author | Kim, Young Joo | - |
dc.contributor.author | Chang, Young Soo | - |
dc.contributor.author | Lee, Hak Jeong | - |
dc.contributor.author | Son, Miwon | - |
dc.contributor.author | Lee, Jung Woo | - |
dc.contributor.author | Yoon, Heung Sik | - |
dc.contributor.author | Kang, Won Jun | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Chung, June-Key | - |
dc.contributor.author | Lee, Myung Chul | - |
dc.contributor.author | Suh, Young-Ger | - |
dc.date.accessioned | 2010-01-06T04:07:12Z | - |
dc.date.available | 2010-01-06T04:07:12Z | - |
dc.date.issued | 2006-10-03 | - |
dc.identifier.citation | Appl Radiat Isot. 2007 Jan;65(1):64-9. Epub 2006 Sep 28. | en |
dc.identifier.issn | 0969-8043 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TJ0-4M0J4DP-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3e41c04004cc24a1ba9bbd5044745eaf | - |
dc.identifier.uri | https://hdl.handle.net/10371/26061 | - |
dc.description.abstract | A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Acetylation | en |
dc.subject | Animals | en |
dc.subject | Equipment Design | en |
dc.subject | Equipment Failure Analysis | en |
dc.subject | Iodized Oil/*chemical synthesis/diagnostic | en |
dc.subject | use/*pharmacokinetics/therapeutic use | en |
dc.subject | Isotope Labeling/*instrumentation/methods | en |
dc.subject | Metabolic Clearance Rate | en |
dc.subject | Mice | en |
dc.subject | Organ Specificity | en |
dc.subject | Organometallic Compounds/*chemical synthesis/diagnostic | en |
dc.subject | use/*pharmacokinetics/therapeutic use | en |
dc.subject | Radiopharmaceuticals/chemical synthesis/diagnostic | en |
dc.subject | use/pharmacokinetics/therapeutic use | en |
dc.subject | Tissue Distribution | en |
dc.subject | Reagent Kits, Diagnostic | - |
dc.title | Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이윤상 | - |
dc.contributor.AlternativeAuthor | 정재민 | - |
dc.contributor.AlternativeAuthor | 김영주 | - |
dc.contributor.AlternativeAuthor | 장영수 | - |
dc.contributor.AlternativeAuthor | 이학정 | - |
dc.contributor.AlternativeAuthor | 손미원 | - |
dc.contributor.AlternativeAuthor | 이정우 | - |
dc.contributor.AlternativeAuthor | 윤흥식 | - |
dc.contributor.AlternativeAuthor | 강원준 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.contributor.AlternativeAuthor | 정준기 | - |
dc.contributor.AlternativeAuthor | 이명철 | - |
dc.contributor.AlternativeAuthor | 서영거 | - |
dc.identifier.doi | 10.1016/j.apradiso.2006.07.008 | - |
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