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The activation of ERK1/2 via a tyrosine kinase pathway attenuates trail-induced apoptosis in HeLa cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Myoung Woo | - |
dc.contributor.author | Bach, Jae Hyun | - |
dc.contributor.author | Lee, Hyun Jung | - |
dc.contributor.author | Lee, Do Yeon | - |
dc.contributor.author | Joo, Wan Seok | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.contributor.author | Park, Soon Cheol | - |
dc.contributor.author | Kim, Kyung Yong | - |
dc.contributor.author | Lee, Won Bok | - |
dc.contributor.author | Kim, Sung Su | - |
dc.date.accessioned | 2010-01-06T06:47:38Z | - |
dc.date.available | 2010-01-06T06:47:38Z | - |
dc.date.issued | 2005-11-25 | - |
dc.identifier.citation | Cancer Invest. 2005;23(7):586-92. | en |
dc.identifier.issn | 0735-7907 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16305985 | - |
dc.identifier.uri | https://hdl.handle.net/10371/26605 | - |
dc.description.abstract | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) serves as an extracellular signal that triggers apoptosis in tumor cells. To characterize the molecular events involved in TRAIL-induced apoptotic signaling, we investigated the role of extracellular signal-regulated kinase 1/2 (ERK1/2) in HeLa cell death. Here we show that TRAIL-activated ERK1/2 through a tyrosine kinase-dependent pathway, subsequently elevated anti-apoptotic Bcl-2 protein levels. ERK1/2 inhibition with PD98059 promoted apoptotic cell death through the downregulation of ERK1/2 activity and Bcl-2 protein levels. Moreover, tyrosine kinase inhibition with Genistein in TRAIL-induced apoptosis effectively attenuated ERK1/2 activity and enhanced apoptotic cell death. Taken together, our results indicate that ERK1/2 activation via tyrosine kinase pathway plays a protective role as the cellular defense mechanism through the upregulation of Bcl-2 protein levels in TRAIL-induced apoptosis. | en |
dc.language.iso | en | en |
dc.publisher | Taylor & Francis | en |
dc.subject | Apoptosis Regulatory Proteins/*physiology | en |
dc.subject | Down-Regulation | en |
dc.subject | Enzyme Activation | en |
dc.subject | Genes, bcl-2 | en |
dc.subject | Hela Cells | en |
dc.subject | Humans | en |
dc.subject | Membrane Glycoproteins/*physiology | en |
dc.subject | Mitogen-Activated Protein Kinase 3/*metabolism | en |
dc.subject | Protein-Tyrosine Kinases/metabolism | en |
dc.subject | Signal Transduction | en |
dc.subject | TNF-Related Apoptosis-Inducing Ligand | en |
dc.subject | Tumor Necrosis Factor-alpha/*physiology | en |
dc.subject | Up-Regulation | en |
dc.subject | Apoptosis | - |
dc.title | The activation of ERK1/2 via a tyrosine kinase pathway attenuates trail-induced apoptosis in HeLa cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이명우 | - |
dc.contributor.AlternativeAuthor | 박재형 | - |
dc.contributor.AlternativeAuthor | 이현정 | - |
dc.contributor.AlternativeAuthor | 이도연 | - |
dc.contributor.AlternativeAuthor | 주완석 | - |
dc.contributor.AlternativeAuthor | 김용식 | - |
dc.contributor.AlternativeAuthor | 박순철 | - |
dc.contributor.AlternativeAuthor | 김경용 | - |
dc.contributor.AlternativeAuthor | 이원복 | - |
dc.contributor.AlternativeAuthor | 김성수 | - |
dc.identifier.doi | 10.1080/07357900500283036 | - |
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