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Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review

Cited 104 time in Web of Science Cited 114 time in Scopus
Authors
Raimondi, S.; Paracchini, V.; Autrup, H.; Barros-Dios, J. M.; Benhamou, S.; Boffetta, P.; Cote, M. L.; Dialyna, I. A.; Dolzan, V.; Filiberti, R.; Garte, S.; Hirvonen, A.; Husgafvel-Pursiainen, K.; Imyanitov, E. N.; Kalina, I.; Kang, D.; Kiyohara, C.; Kohno, T.; Kremers, P.; Lan, Q.; London, S.; Povey, A. C.; Rannug, A.; Reszka, E.; Risch, A.; Romkes, M.; Schneider, J.; Seow, A.; Shields, P. G.; Sobti, R. C.; Sorensen, M.; Spinola, M.; Spitz, M. R.; Strange, R. C.; Stucker, I.; Sugimura, H.; To-Figueras, J.; Tokudome, S.; Yang, P.; Yuan, J. M.; Warholm, M.; Taioli, E.
Issue Date
2006-09-27
Publisher
Oxford University Press
Citation
Am J Epidemiol. 2006 Dec 1;164(11):1027-42. Epub 2006 Sep 25.
Keywords
Asian Continental Ancestry Group/statistics & numerical dataCase-Control StudiesData Interpretation, StatisticalEuropean Continental Ancestry Group/statistics & numerical dataGenetic Predisposition to DiseaseGenetic VariationGenotypeGlutathione Transferase/*genetics/physiologyHumansLung Neoplasms/*enzymology/ethnology/*geneticsPolymorphism, GeneticRisk FactorsSmoking/adverse effects
Abstract
Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.
ISSN
0002-9262 (Print)
Language
English
URI
http://hdl.handle.net/10371/26627
DOI
https://doi.org/10.1093/aje/kwj321
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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