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Treatment of hypoxic-ischemic encephalopathy in mouse by transplantation of embryonic stem cell-derived cells

Cited 25 time in Web of Science Cited 35 time in Scopus
Authors
Ma, Jie; Wang, Yu; Yang, Jianhua; Yang, Min; Chang, Keun-A; Zhang, Linhua; Jiang, Feng; Li, Yi; Zhang, Zhonggong; Heo, Chaejeong; Suh, Yoo-Hun
Issue Date
2007-05-29
Publisher
Elsevier
Citation
Neurochem Int. 2007 Jul;51(1):57-65. Epub 2007 Apr 29.
Keywords
AnimalsAnimals, NewbornBiological Markers/analysis/metabolismBrain Infarction/metabolism/physiopathology/therapyCell Differentiation/*physiologyCell LineCerebral Cortex/metabolism/pathology/physiopathologyEmbryonic Stem Cells/metabolism/*transplantationGraft Survival/*physiologyHippocampus/metabolism/pathology/physiopathologyHypoxia-Ischemia, Brain/metabolism/physiopathology/*therapyIntermediate Filament Proteins/geneticsMemory Disorders/metabolism/physiopathology/therapyMiceMice, Inbred C57BLMicrotubule-Associated Proteins/geneticsNerve Degeneration/metabolism/physiopathology/therapyNerve Tissue Proteins/geneticsNeurons/*metabolismRNA, Messenger/metabolismStem Cell Transplantation/*methodsTreatment Outcome
Abstract
A 7-day-old hypoxic-ischemic encephalopathy (HIE) mouse model was used to study the effect of transplantation of embryonic stem (ES) cell-derived cells on the HIE. After the inducement in vitro, the ES cell-derived cells expressed Nestin and MAP-2, rather than GFAP mRNA. After transplantation, ES cell-derived cells can survive, migrate into the injury site, and specifically differentiate into neurons, showing improvement of the learning ability and memory of the HIE mouse at 8 months post-transplantation. The non-grafted HIE mouse brain showed typical pathological changes in the hippocampus and cerebral cortex, where the number of neurons was reduced, while in the cell graft group, number of the neurons increased in the same regions. Although further study is necessary to elucidate the precise mechanisms responsible for this functional recovery, we believe that ES cells have advantages for use as a donor source in HIE.
ISSN
0197-0186 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17531351

http://hdl.handle.net/10371/26856
DOI
https://doi.org/10.1016/j.neuint.2007.04.012
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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