S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Decreased blood flow of temporal regions of the brain in subjects with panic disorder
- Lee, Yujin S; Hwang, Jaeuk; Kim, Seog Ju; Sung, Young Hoon; Kim, Jihyun; Sim, Minyoung E; Bae, Soojeong C; Kim, Minue J; Lyoo, In Kyoon
- Issue Date
- J Psychiatr Res. 2006 Sep;40(6):528-34. Epub 2005 Oct 18.
- Adult; Analysis of Variance; Blood Flow Velocity/physiology; Brain Mapping; Case-Control Studies; Demography; Female; Humans; Male; Panic Disorder/physiopathology/*radionuclide imaging; Reference Values; Regional Blood Flow/physiology; Temporal Lobe/*blood supply/physiopathology/*radionuclide imaging; Tomography, Emission-Computed, Single-Photon/methods
- OBJECT: The purpose of the current study was to investigate alterations of regional cerebral blood flow (rCBF) in subjects with panic disorder. METHODS: Twenty-two subjects with panic disorder who were under psychotropic medications and 25 age and gender-matched healthy comparison subjects were assessed regarding the rCBF of using Tc-99m-hexamethyl propylenamino oxime single photon emission tomography (SPECT). Using statistical parametric mapping, the rCBF was compared between panic disorder and healthy comparison groups. RESULTS: Decreased rCBF flow in right superior temporal lobe was observed in subjects with panic disorder (p<0.05 after correction for multiple comparisons). The rCBF in right superior temporal gyrus negatively correlated with the duration of illness, scores of panic disorder severity scale (PDSS), Hamilton anxiety rating scale (HARS) and Zung self-rating anxiety scale (Z-SAS). CONCLUSION: We report that there is a decreased cerebral blood flow of temporal regions of the brain in panic disorder and that this decrease may, in part, reflect the clinical severity of panic disorder.
- 0022-3956 (Print)
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