S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Biochemistry & Molecular Biology (생화학교실) Journal Papers (저널논문_생화학교실)
Intellect declines in healthy elderly subjects and cerebellum
- Lee, Jun-Young; Lyoo, In Kyoon; Kim, Seon-Uk; Jang, Hong-Suk; Lee, Dong-Woo; Jeon, Hong-Jin; Park, Sang-Chul; Cho, Maeng Je
- Issue Date
- Psychiatry Clin Neurosci. 2005 Feb;59(1):45-51.
- Aged; Aging/*physiology; Atrophy; Cerebellum/*pathology; Cerebral Cortex/*pathology; Dominance, Cerebral/physiology; Female; Frontal Lobe/pathology; Humans; *Image Processing, Computer-Assisted; *Imaging, Three-Dimensional; Intelligence/*physiology; *Magnetic Resonance Imaging; Male; Middle Aged; Psychometrics/statistics & numerical data; Statistics as Topic; Wechsler Scales/statistics & numerical data
- Scores of the performance scale of the Wechsler Adult Intelligence Scale (WAIS) declined linearly with age from the 6th decade, whereas those of the verbal scale did not. This decrease in performance intelligence was thought to be related to an age-related frontal atrophy. The relationship between scores of the WAIS and changes in regional cortical gray matter density were examined in healthy elderly subjects using voxel-based morphometry. Thirty healthy non-demented individuals >50 years of age were tested with the WAIS and scanned with brain magnetic resonance imaging (MRI). The right neocerebellum was significantly associated with scores of the performance intelligence scale while frontal lobes were not. The current study suggests that the cerebellum may play an important role in changes of intellectual capacity in old age.
- 1323-1316 (Print)
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