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Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Dohyun | - |
dc.contributor.author | Oh, Jongkil | - |
dc.contributor.author | Kim, Kyunggon | - |
dc.contributor.author | Lim, Hyosun | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.date.accessioned | 2010-01-07T02:35:15Z | - |
dc.date.available | 2010-01-07T02:35:15Z | - |
dc.date.issued | 2007-07-13 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 2007 Sep 7;360(4):784-90. Epub 2007 Jul 5. | en |
dc.identifier.issn | 0006-291X (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4P48623-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=842ac4e3b02bc01a6a714438ee40fa46 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17624311 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27908 | - |
dc.description.abstract | YrrB is a hypothetical protein containing a tetratricopeptide repeat (TPR) domain from a Gram-positive bacterium, Bacillus subtilis. We determined YrrB structure in the C2 space group to 2.5A resolution, which is the first TPR structure of the Gram-positive bacterium B. subtilis. In contrast to other known TPR structures, the concave surface of the YrrB TPR domain is composed of the putative peptide-binding pocket lined with positively-charged residues. This unique charge distribution reveals that YrrB can interact with partner proteins via an unusual TPR-mediated interaction mode, compared to that of other TPR-containing structures. Functional annotation using genomics analysis suggested that YrrB may be an interacting mediator in the complex formation among RNA sulfuration components. No proteins containing a TPR domain have been identified in the biosynthesis of sulfur-containing biomolecules. Thus, YrrB could play a new role as a connecting module among those proteins in the conserved gene cluster for RNA sulfuration. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Amino Acid Sequence | en |
dc.subject | Bacillus subtilis/chemistry | en |
dc.subject | Bacterial Proteins/*chemistry/metabolism | en |
dc.subject | Binding Sites | en |
dc.subject | Crystallography, X-Ray | en |
dc.subject | Molecular Sequence Data | en |
dc.subject | Peptides/*metabolism | en |
dc.subject | Protein Conformation | en |
dc.subject | Repetitive Sequences, Amino Acid | en |
dc.subject | Sequence Homology, Amino Acid | en |
dc.title | Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 한도현 | - |
dc.contributor.AlternativeAuthor | 오종길 | - |
dc.contributor.AlternativeAuthor | 김경곤 | - |
dc.contributor.AlternativeAuthor | 임효선 | - |
dc.contributor.AlternativeAuthor | 김영수 | - |
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