Browse

Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students

Cited 13 time in Web of Science Cited 16 time in Scopus
Authors
Ham, Byung-Joo; Lee, Young-Mee; Kim, Meyoung-Kon; Lee, Juneyoung; Ahn, Duck-Sun; Choi, Myoung-Jin; Lyoo, In Kyoon; Choi, Ihn-Geun; Lee, Min-Soo
Issue Date
2007-07-29
Publisher
Karger
Citation
Neuropsychobiology. 2006;53(4):203-9. Epub 2006 Jul 26.
Keywords
AdultChi-Square Distribution*Educational Status*ExonsFemaleGene FrequencyGenotypeHumansMaleMinisatellite Repeats/*geneticsPersonality/*geneticsPersonality Inventory*Polymorphism, GeneticRNA, Messenger/metabolismReceptors, Dopamine D4/*geneticsRegression AnalysisReverse Transcriptase Polymerase Chain Reaction/methodsSex FactorsStudents, Medical
Abstract
This study investigated the relationships between genetic polymorphisms, personality traits, and academic achievement in medical school students. Study subjects were 220 1st-year medical students at Korea University Medical School during two consecutive academic years (2003-2004). Grade-point averages (GPA) during the second semester of the 1st year of the medical school were obtained as a measure of academic achievement. In addition, all participants completed the Temperament and Character Inventory and questionnaires on depression and anxiety. The polymorphisms in exon III of the dopamine D4 receptor (DRD4) were determined using the polymerase chain reaction. Our results revealed that both male and female subjects with a higher GPA may be characterized as having higher persistence and lower novelty seeking traits. In addition, male subjects with high GPA had higher scores in self directedness and female subjects with a higher GPA may be characterized as having higher scores in harm avoidance. Male students with 4-repeat alleles had a significantly lower GPA than male students without 4-repeat alleles.This relationship also remained after controlling for the personality variables, none of which showed a relationship with the polymorphism after Bonferroni correction. For females, however, no associations could be found between GPA and the polymorphism. Thus, the present study demonstrated for the first time a possible influence of the DRD4 48 bp variable number of tandem repeats polymorphism on academic achievement and proved that this was not mediated by performance-associated personality traits.
ISSN
0302-282X (Print)
Language
English
URI
http://content.karger.com/produktedb/produkte.asp?typ=pdf&file=NPS2006053004203

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16874007

http://hdl.handle.net/10371/29069
DOI
https://doi.org/10.1159/000094729
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse