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Phase II study of low-dose paclitaxel and cisplatin as a second-line therapy after 5-fluorouracil/platinum chemotherapy in gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Keun-Wook | - |
dc.contributor.author | Kim, Jee Hyun | - |
dc.contributor.author | Yun, Tak | - |
dc.contributor.author | Song, Eun Kee | - |
dc.contributor.author | Na, Im Il | - |
dc.contributor.author | Shin, Hytinchoon | - |
dc.contributor.author | Oh, So Yeon | - |
dc.contributor.author | Choi, In Sil | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Lee, Jong Seok | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Kim, Noe Kyeong | - |
dc.date.accessioned | 2010-01-12T01:21:59Z | - |
dc.date.available | 2010-01-12T01:21:59Z | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2007-09 | - |
dc.identifier.citation | Journal of Korean Medical Science, Vol.22, pp.S115-S121 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.other | 95281 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29485 | - |
dc.description.abstract | This study was performed to evaluate the efficacy and toxicity of low-dose paclitaxel/cisplatin chemotherapy in patients with metastatic or recurrent gastric cancer that had failed 5-fluorouracil/platinum-based chemotherapy. Thirty-two patients with documented progression on or within 6 months after discontinuing 5-fluorouracil/platinum-based chemotherapy were enrolled. As a second-line treatment, paclitaxel (145 mg/m(2)) and cisplatin (60 mg/m(2)) was administered on day 1 every 3 weeks, Among 32 patients enrolled, 8 (25%) responded partially to paclitaxel/cisplatin, 8 (25%) had stable disease, and 14 (44%) had progressive disease. Two patients (6%) were not evaluable. The median time to progression (TTP) and overall survival for all patients were 2.9 months and 9.1 months, respectively. The most common hematologic toxicity was anemia (47%). Grade 3 neutropenia developed in but no other grade 3/4 hematologic toxicity occurred. The most three patients (9%), common non-hematologic toxicities were emesis (31%) and peripheral neuropathy (38%). Three cases (9%) of grade 3/4 emesis and 2 cases (6%) of grade 3 peripheral neuropathy developed. In conclusion, low-dose paclitaxel and cisplatin chemotherapy showed moderate activity with favorable toxicity profiles. However, relatively short TTP of this regimen warrants the development of more effective paclitaxel-based regimens other than combination with cisplatin in these patients as second-line therapies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한의학회 | - |
dc.title | Phase II study of low-dose paclitaxel and cisplatin as a second-line therapy after 5-fluorouracil/platinum chemotherapy in gastric cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.citation.journaltitle | Journal of Korean Medical Science | - |
dc.identifier.wosid | 000251243100020 | - |
dc.identifier.scopusid | 2-s2.0-36148987169 | - |
dc.citation.endpage | S121 | - |
dc.citation.startpage | S115 | - |
dc.citation.volume | 22 | - |
dc.identifier.sci | 000251243100020 | - |
dc.identifier.kciid | ART001090077 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Lee, Jong Seok | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Kim, Noe Kyeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | METASTATIC BREAST-CANCER | - |
dc.subject.keywordPlus | COMBINATION CHEMOTHERAPY | - |
dc.subject.keywordPlus | RANDOMIZED-TRIAL | - |
dc.subject.keywordPlus | 3-HOUR INFUSION | - |
dc.subject.keywordPlus | SUPPORTIVE CARE | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | CARBOPLATIN | - |
dc.subject.keywordPlus | PLUS | - |
dc.subject.keywordPlus | METHOTREXATE | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | paclitaxel | - |
dc.subject.keywordAuthor | cisplatin | - |
dc.subject.keywordAuthor | gastric cancer | - |
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