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Frontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET study

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Authors
Lee, Dong Young; Choo, Il Han; Jhoo, Jin Hyeong; Kim, Ki Woong; Youn, Jong Choul; Lee, Dong Su; Kang, Eun Joo; Lee, Jae Sung; Kang, Won Jun; Woo, Jong In
Issue Date
2006-07-04
Publisher
American Association for Geriatric Psychiatry
Citation
Am J Geriatr Psychiatry. 2006 Jul;14(7):625-8.
Keywords
AgedAlzheimer Disease/*physiopathology/*radionuclide imagingDepressive Disorder, Major/*physiopathology/*radionuclide imagingFemaleFluorodeoxyglucose F18/*diagnostic use/*pharmacokineticsFrontal Lobe/*metabolism/*physiopathologyHumansMale*Positron-Emission TomographyRadiopharmaceuticals/*diagnostic use/*pharmacokinetics
Abstract
OBJECTIVE: This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD). METHOD: Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method. RESULTS: The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group. CONCLUSIONS: These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.
ISSN
1064-7481 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16816017

http://hdl.handle.net/10371/29693
DOI
https://doi.org/10.1097/01.JGP.0000214541.79965.2d
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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