S-Space College of Medicine/School of Medicine (의과대학/대학원) Nuclear Medicine (핵의학전공) Journal Papers (저널논문_핵의학전공)
Frontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET study
- Lee, Dong Young; Choo, Il Han; Jhoo, Jin Hyeong; Kim, Ki Woong; Youn, Jong Choul; Lee, Dong Su; Kang, Eun Joo; Lee, Jae Sung; Kang, Won Jun; Woo, Jong In
- Issue Date
- Am J Geriatr Psychiatry. 2006 Jul;14(7):625-8.
- Aged; Alzheimer Disease/*physiopathology/*radionuclide imaging; Depressive Disorder, Major/*physiopathology/*radionuclide imaging; Female; Fluorodeoxyglucose F18/*diagnostic use/*pharmacokinetics; Frontal Lobe/*metabolism/*physiopathology; Humans; Male; *Positron-Emission Tomography; Radiopharmaceuticals/*diagnostic use/*pharmacokinetics
- OBJECTIVE: This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD). METHOD: Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method. RESULTS: The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group. CONCLUSIONS: These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.
- 1064-7481 (Print)
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