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Effects of intravascular volume therapy using hydroxyethyl starch (130/0.4) on post-operative bleeding and transfusion requirements in children undergoing cardiac surgery: a randomized clinical trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Chong Sung | - |
dc.contributor.author | Park, Kum Suk | - |
dc.contributor.author | Yoon, Mi Ja | - |
dc.contributor.author | Kim, Kyoung Ok | - |
dc.date.accessioned | 2010-01-12T05:55:24Z | - |
dc.date.available | 2010-01-12T05:55:24Z | - |
dc.date.issued | 2006-02-03 | - |
dc.identifier.citation | Acta Anaesthesiol Scand. 2006 Jan;50(1):108-11. | en |
dc.identifier.issn | 0001-5172 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16451158 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29700 | - |
dc.description.abstract | BACKGROUND: Hydroxyethyl starch (HES) used for intravascular volume expansion may cause coagulation abnormalities, especially in cardiac patients. Although low molecular weight HES (130/0.4) has been developed to minimize its influence on coagulation, experience with HES (130/0.4) in children is limited. Therefore, we evaluated the effects of a HES (130/0.4) infusion on post-operative blood loss in children undergoing cardiac surgery. METHODS: Forty-two children undergoing cardiac surgery were assigned at random to receive either 10 ml/kg fresh frozen plasma (FFP group; n=21) or HES (130/0.4) (HES group; n=21) shortly after cardiopulmonary bypass termination. Activated partial thromboplastin time (aPTT) and international normalization ratio (INR) were measured. In addition, post-operative transfusion requirements and blood loss until the end of the first post-operative day were compared. RESULTS: INR was significantly prolonged after HES infusion in comparison to the FFP group (P<0.05). During the first 24 h after surgery, post-operative blood loss, the use of allogenic blood/blood products and aPTT were similar in all children. CONCLUSIONS: Our study shows that the administration of a moderate dose of HES (130/0.4) in children undergoing cardiac surgery does not cause more bleeding or a higher transfusion requirement than a FFP infusion, and suggests that the administration of 10 ml/kg HES (130/0.4) is a safe alternative to plasma for intravascular volume replacement in this patient population. | en |
dc.language.iso | en | en |
dc.publisher | Munksgaard | en |
dc.subject | Cardiopulmonary Bypass | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Heart Defects, Congenital/surgery | en |
dc.subject | Hetastarch/*administration & dosage | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | International Normalized Ratio | en |
dc.subject | Molecular Weight | en |
dc.subject | Partial Thromboplastin Time | en |
dc.subject | Plasma | en |
dc.subject | Plasma Substitutes/*administration & dosage | en |
dc.subject | Postoperative Care | en |
dc.subject | Postoperative Hemorrhage/*therapy | en |
dc.subject | Blood Transfusion | - |
dc.subject | Cardiac Surgical Procedures | - |
dc.title | Effects of intravascular volume therapy using hydroxyethyl starch (130/0.4) on post-operative bleeding and transfusion requirements in children undergoing cardiac surgery: a randomized clinical trial | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김종성 | - |
dc.contributor.AlternativeAuthor | 박금숙 | - |
dc.contributor.AlternativeAuthor | 윤미자 | - |
dc.contributor.AlternativeAuthor | 김경옥 | - |
dc.identifier.doi | 10.1111/j.1399-6576.2005.00881.x | - |
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