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Effects of intravascular volume therapy using hydroxyethyl starch (130/0.4) on post-operative bleeding and transfusion requirements in children undergoing cardiac surgery: a randomized clinical trial

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dc.contributor.authorKim, Chong Sung-
dc.contributor.authorPark, Kum Suk-
dc.contributor.authorYoon, Mi Ja-
dc.contributor.authorKim, Kyoung Ok-
dc.date.accessioned2010-01-12T05:55:24Z-
dc.date.available2010-01-12T05:55:24Z-
dc.date.issued2006-02-03-
dc.identifier.citationActa Anaesthesiol Scand. 2006 Jan;50(1):108-11.en
dc.identifier.issn0001-5172 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16451158-
dc.identifier.urihttps://hdl.handle.net/10371/29700-
dc.description.abstractBACKGROUND: Hydroxyethyl starch (HES) used for intravascular volume expansion may cause coagulation abnormalities, especially in cardiac patients. Although low molecular weight HES (130/0.4) has been developed to minimize its influence on coagulation, experience with HES (130/0.4) in children is limited. Therefore, we evaluated the effects of a HES (130/0.4) infusion on post-operative blood loss in children undergoing cardiac surgery. METHODS: Forty-two children undergoing cardiac surgery were assigned at random to receive either 10 ml/kg fresh frozen plasma (FFP group; n=21) or HES (130/0.4) (HES group; n=21) shortly after cardiopulmonary bypass termination. Activated partial thromboplastin time (aPTT) and international normalization ratio (INR) were measured. In addition, post-operative transfusion requirements and blood loss until the end of the first post-operative day were compared. RESULTS: INR was significantly prolonged after HES infusion in comparison to the FFP group (P<0.05). During the first 24 h after surgery, post-operative blood loss, the use of allogenic blood/blood products and aPTT were similar in all children. CONCLUSIONS: Our study shows that the administration of a moderate dose of HES (130/0.4) in children undergoing cardiac surgery does not cause more bleeding or a higher transfusion requirement than a FFP infusion, and suggests that the administration of 10 ml/kg HES (130/0.4) is a safe alternative to plasma for intravascular volume replacement in this patient population.en
dc.language.isoenen
dc.publisherMunksgaarden
dc.subjectCardiopulmonary Bypassen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectHeart Defects, Congenital/surgeryen
dc.subjectHetastarch/*administration & dosageen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInternational Normalized Ratioen
dc.subjectMolecular Weighten
dc.subjectPartial Thromboplastin Timeen
dc.subjectPlasmaen
dc.subjectPlasma Substitutes/*administration & dosageen
dc.subjectPostoperative Careen
dc.subjectPostoperative Hemorrhage/*therapyen
dc.subjectBlood Transfusion-
dc.subjectCardiac Surgical Procedures-
dc.titleEffects of intravascular volume therapy using hydroxyethyl starch (130/0.4) on post-operative bleeding and transfusion requirements in children undergoing cardiac surgery: a randomized clinical trialen
dc.typeArticleen
dc.contributor.AlternativeAuthor김종성-
dc.contributor.AlternativeAuthor박금숙-
dc.contributor.AlternativeAuthor윤미자-
dc.contributor.AlternativeAuthor김경옥-
dc.identifier.doi10.1111/j.1399-6576.2005.00881.x-
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