S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
White matter changes associated with psychotic symptoms in Alzheimer's disease patients
- Lee, Dong Young; Choo, Il Han; Kim, Ki Woong; Jhoo, Jin Hyeong; Youn, Jong Choul; Lee, Un Young; Woo, Jong Inn
- Issue Date
- American Psychiatric Publishing
- J Neuropsychiatry Clin Neurosci. 2006 Spring;18(2):191-8.
- Aged; Alzheimer Disease/*diagnosis/psychology; Basal Ganglia/pathology; Brain/*pathology; Capgras Syndrome/diagnosis/psychology; Cerebral Cortex/pathology; Delusions/diagnosis/psychology; Dominance, Cerebral/physiology; Female; Follow-Up Studies; Humans; *Image Enhancement; *Image Processing, Computer-Assisted; *Magnetic Resonance Imaging; Male; Middle Aged; Psychiatric Status Rating Scales; Psychotic Disorders/*diagnosis/psychology
- This study explored the relationship between white matter changes seen on magnetic resonance imaging (MRI) and neuropsychiatric symptoms of Alzheimer's disease patients. Fifty-five probable Alzheimer's disease patients were assessed with Behavioral Rating Scale for Dementia (BRSD) and MRI. White matter changes in the bilateral frontal or parieto-occipital region and left basal ganglia significantly corresponded with the score of the Psychotic Symptoms subscale of BRSD. Secondary analyses revealed that white matter changes were not associated with paranoid delusion and hallucination, but only with delusional misidentification. Our results suggest that white matter changes in Alzheimer's disease patients probably contribute to the development of specific psychotic symptoms, namely delusional misidentification.
- 0895-0172 (Print)
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