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White matter changes associated with psychotic symptoms in Alzheimer's disease patients

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Authors
Lee, Dong Young; Choo, Il Han; Kim, Ki Woong; Jhoo, Jin Hyeong; Youn, Jong Choul; Lee, Un Young; Woo, Jong Inn
Issue Date
2006-05-25
Publisher
American Psychiatric Publishing
Citation
J Neuropsychiatry Clin Neurosci. 2006 Spring;18(2):191-8.
Keywords
AgedAlzheimer Disease/*diagnosis/psychologyBasal Ganglia/pathologyBrain/*pathologyCapgras Syndrome/diagnosis/psychologyCerebral Cortex/pathologyDelusions/diagnosis/psychologyDominance, Cerebral/physiologyFemaleFollow-Up StudiesHumans*Image Enhancement*Image Processing, Computer-Assisted*Magnetic Resonance ImagingMaleMiddle AgedPsychiatric Status Rating ScalesPsychotic Disorders/*diagnosis/psychology
Abstract
This study explored the relationship between white matter changes seen on magnetic resonance imaging (MRI) and neuropsychiatric symptoms of Alzheimer's disease patients. Fifty-five probable Alzheimer's disease patients were assessed with Behavioral Rating Scale for Dementia (BRSD) and MRI. White matter changes in the bilateral frontal or parieto-occipital region and left basal ganglia significantly corresponded with the score of the Psychotic Symptoms subscale of BRSD. Secondary analyses revealed that white matter changes were not associated with paranoid delusion and hallucination, but only with delusional misidentification. Our results suggest that white matter changes in Alzheimer's disease patients probably contribute to the development of specific psychotic symptoms, namely delusional misidentification.
ISSN
0895-0172 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16720796

http://hdl.handle.net/10371/29703
DOI
https://doi.org/10.1176/appi.neuropsych.18.2.191
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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