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Dopamine transporter SPECT of a liver cirrhotic with atypical parkinsonism

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Authors
Kim, Jongchul; Kim, Jong-Min; Kim, Yu Kyeong; Shin, Jung Woo; Choi, Seong Hoon; Kim, Sang Eun; Kim, Yangho
Issue Date
2007
Publisher
National Institute of Industrial Health
Citation
Industrial Health 45(3): 497-500
Keywords
AdultDiagnosis, Differential*Dopamine Plasma Membrane Transport ProteinsGlobus PallidusHumans*Liver CirrhosisMaleManganese/*toxicityParkinsonian Disorders/*diagnosis/physiopathologyTomography, Emission-Computed, Single-Photon/*instrumentation
Abstract
High level of exposure to manganese (Mn) can cause a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of [123I]-fluoropropyl (FP)-CIT SPECT of a liver cirrhotic with atypical parkinsonism. The patient developed atypical parkinsonian features associated with elevated blood Mn from hepatic dysfunction. [123I]-FP-CIT brain SPECT images of dopamine transporter (DAT) demonstrated overall normal range of DAT uptake in the striatum although there were scattered small hypodense regions. The globus pallidum had increased signal on T1-weighted magnetic resonance imaging (MRI). All these findings are compatible with those of manganism, and are remarkably different from that in PD.
ISSN
0019-8366 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17634700

http://hdl.handle.net/10371/29862
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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