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Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells

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Authors
Lee, Jung Weon; Ko, Seong Gyu; Kim, Hwang-Phill; Jin, Dong-Hoon; Bae, Hyun-Su; Kim, Sung Hoon; Park, Chong-Hyeong
Issue Date
2004
Publisher
Elsevier
Citation
Cancer Letters 220 (2005) 11–19
Keywords
Saussurea lappa; Apoptosis; Gastric cancer; p53; Growth arrest; ATM/ATR
Abstract
The molecular effects of Saussurea lappa extracts, a traditional medicine in Eastern Asia, on the fate of gastric carcinoma
have not been understood. In this study, its cytostatic effects were examined using gastric AGS cancer cells. Its treatment
resulted in apoptosis and G2-arrest in a dose- and time-dependent manner. The effects were attributed to the regulation of
cyclins and pro-apoptotic molecules and suppression of anti-apoptotic molecules. Therefore, these results suggest that extracts
of S. lappa root may be a candidate to deal with gastric cancers either by traditional herbal therapy or by combinational therapy
with conventional chemotherapy.
ISSN
0304-3835
Language
English
URI
http://www.elsevier.com/locate/canlet
http://hdl.handle.net/10371/3242
DOI
https://doi.org/10.1016/j.canlet.2004.06.026
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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