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Polymorphisms in the ghrelin gene are associated with serum high-density lipoprotein cholesterol level and not with type 2 diabetes mellitus in Koreans
DC Field | Value | Language |
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dc.contributor.author | Choi, Hyung Jin | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Moon, Min Kyong | - |
dc.contributor.author | Choi, Hye Hun | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Jang, Hak Chul | - |
dc.contributor.author | Kim, Seong Yeon | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.date.accessioned | 2010-01-19T14:08:45Z | - |
dc.date.available | 2010-01-19T14:08:45Z | - |
dc.date.issued | 2006-09-07 | - |
dc.identifier.citation | J Clin Endocrinol Metab. 2006 Nov;91(11):4657-63. Epub 2006 Sep 5. | en |
dc.identifier.issn | 0021-972X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16954159 | - |
dc.identifier.uri | https://hdl.handle.net/10371/38220 | - |
dc.description.abstract | CONTEXT: Ghrelin is known to play a role in glucose metabolism and in beta-cell function. There are controversies regarding the role of ghrelin polymorphisms in diabetes and diabetes-related phenotypes. OBJECTIVE: The objective of this study was to examine polymorphisms of the ghrelin gene in a Korean cohort and investigate associations between them and susceptibility to type 2 diabetes and its related phenotypes. DESIGN AND PATIENTS: The ghrelin gene was sequenced to identify polymorphisms in 24 DNA samples. Common variants were then genotyped in 760 type 2 diabetic patients and 641 nondiabetic subjects. Genetic associations with diabetes-related phenotypes were also analyzed. RESULTS: Nine polymorphisms were identified, and four common polymorphisms [g.-1500C>G, g.-1062G > C, g.-994C > T, g.+408C > A (Leu72Met)] were genotyped in a larger study. The genotype distributions of these four common polymorphisms in type 2 diabetes patients were similar to those of normal nondiabetic controls. However, these four common polymorphisms were variably associated with several diabetes-related phenotypes, such as high-density lipoprotein (HDL) cholesterol, fasting plasma glucose, and homeostasis model assessment of insulin resistance. In particular, subjects harboring g.-1062C were associated with a lower serum HDL cholesterol level after adjusting for other variables (P = 0.0004 or 0.01 after Bonferroni correction for 24 tests). CONCLUSION: The aforementioned four common polymorphisms in the ghrelin gene were not found to be significantly associated with susceptibility to type 2 diabetes mellitus in the Korean population. However, the common polymorphism g.-1062G > C in the promoter region of the ghrelin gene was found to be significantly associated with serum HDL cholesterol levels. | en |
dc.language.iso | en | en |
dc.publisher | Endocrine Society | en |
dc.subject | Aged | en |
dc.subject | Cholesterol, HDL/*blood | en |
dc.subject | DNA-Binding Proteins/metabolism | en |
dc.subject | Diabetes Mellitus, Type 2/*epidemiology/genetics | en |
dc.subject | Female | en |
dc.subject | Ghrelin | en |
dc.subject | Humans | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Linkage (Genetics) | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Peptide Hormones/*genetics | en |
dc.subject | Phenotype | en |
dc.subject | Promoter Regions, Genetic | en |
dc.subject | Sequence Analysis, DNA | en |
dc.subject | Transcription Factors/metabolism | en |
dc.subject | Transcriptional Activation | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | Polymorphisms in the ghrelin gene are associated with serum high-density lipoprotein cholesterol level and not with type 2 diabetes mellitus in Koreans | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최형진 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 문민경 | - |
dc.contributor.AlternativeAuthor | 최혜훈 | - |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.contributor.AlternativeAuthor | 장학철 | - |
dc.contributor.AlternativeAuthor | 김성연 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.identifier.doi | 10.1210/jc.2005-2549 | - |
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