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SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) polymorphisms are associated with end-stage renal disease in diabetic nephropathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jae Hyeon | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Moon, Min Kyong | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Hwang, Young Hwan | - |
dc.contributor.author | Oh, Kook Whan | - |
dc.contributor.author | Kim, Seong Yeon | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.date.accessioned | 2010-01-20T02:32:06Z | - |
dc.date.available | 2010-01-20T02:32:06Z | - |
dc.date.issued | 2006-03-01 | - |
dc.identifier.citation | Diabetes. 2006 Mar;55(3):843-8. | en |
dc.identifier.issn | 0012-1797 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16505253 | - |
dc.identifier.uri | https://hdl.handle.net/10371/39194 | - |
dc.description.abstract | Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD). Genetic susceptibility plays an important role in the development and progression of diabetic nephropathy. Previous studies have revealed that polymorphisms in the SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute carrier family 12 member 3, might contribute to genetic susceptibility to diabetic nephropathy and essential hypertension. In this study, we examined whether the SLC12A3 gene locus is associated with ESRD resulting from diabetic nephropathy. We genotyped 11 common single nucleotide polymorphisms (SNPs) in the SLC12A3 gene in 177 patients with ESRD due to type 2 diabetes and 184 patients with diabetic retinopathy but with no signs of renal involvement. Three SNPs (g.34372G>A [Arg913Gln], g.39143G>A, and g.41727C>T) were found to be associated with ESRD due to diabetic nephropathy. These three SNPs were in complete linkage disequilibrium. Haplotype 4 in block 2 (18806C, 21822C, 34372A, 39143A, 39240T, 39375C, and 41727T) showed a significant association with ESRD due to type 2 diabetes (P = 0.0028). These results suggest that the SLC12A3 gene locus is associated with ESRD due to diabetic nephropathy. | en |
dc.language.iso | en | en |
dc.publisher | American Diabetes Association | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Diabetic Nephropathies/*genetics | en |
dc.subject | Female | en |
dc.subject | Haplotypes | en |
dc.subject | Humans | en |
dc.subject | Kidney Failure, Chronic/*genetics | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Receptors, Drug/*genetics | en |
dc.subject | Symporters/*genetics | en |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.title | SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) polymorphisms are associated with end-stage renal disease in diabetic nephropathy | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김재현 | - |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.contributor.AlternativeAuthor | 박병래 | - |
dc.contributor.AlternativeAuthor | 문민경 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 황영환 | - |
dc.contributor.AlternativeAuthor | 오국환 | - |
dc.contributor.AlternativeAuthor | 김성연 | - |
dc.contributor.AlternativeAuthor | 안규리 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
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