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Crystal structure of PilF: functional implication in the type 4 pilus biogenesis in Pseudomonas aeruginosa
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyunggon | - |
dc.contributor.author | Oh, Jongkil | - |
dc.contributor.author | Han, Dohyun | - |
dc.contributor.author | Kim, Eunice EunKyeong | - |
dc.contributor.author | Lee, Byungil | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.date.accessioned | 2010-01-20T02:32:41Z | - |
dc.date.available | 2010-01-20T02:32:41Z | - |
dc.date.issued | 2006-01-13 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 2006 Feb 24;340(4):1028-38. Epub 2005 Dec 27. | en |
dc.identifier.issn | 0006-291X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16403447 | - |
dc.identifier.uri | https://hdl.handle.net/10371/39195 | - |
dc.description.abstract | PilF is a requisite protein involved in the type 4 pilus biogenesis system from the Gram-negative human pathogenic bacteria, Pseudomonas aeruginosa. We determined the PilF structure at a 2.2A resolution; this includes six tandem tetratrico peptide repeat (TPR) units forming right-handed superhelix. PilF structure was similar to the heat shock protein organizing protein, which interacts with the C-terminal peptide of Hsp90 and Hsp70 via a concave Asn ladder in the inner groove of TPR superhelix. After simulated screening, the C-terminal pentapeptides of PilG, PilU, PilY, and PilZ proved to be a likely candidate binding to PilF, which are ones of 25 necessary components involved in the type 4 pilus biogenesis system. We proposed that PilF would be critical as a bridgehead in protein-protein interaction and thereby, PilF may bind a necessary molecule in type 4 pilus biogenesis system such as PilG, PilU, PilY, and PilZ. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Amino Acid Sequence | en |
dc.subject | Binding Sites | en |
dc.subject | Biogenesis | en |
dc.subject | Computer Simulation | en |
dc.subject | Crystallography | en |
dc.subject | Dimerization | en |
dc.subject | Fimbriae Proteins/*chemistry/metabolism/*ultrastructure | en |
dc.subject | Fimbriae, Bacterial/*chemistry/physiology/ultrastructure | en |
dc.subject | Models, Biological | en |
dc.subject | Molecular Sequence Data | en |
dc.subject | Multiprotein Complexes/chemistry/ultrastructure | en |
dc.subject | Protein Binding | en |
dc.subject | Protein Conformation | en |
dc.subject | Pseudomonas aeruginosa/*chemistry/growth & development/ultrastructure | en |
dc.subject | Structure-Activity Relationship | en |
dc.subject | Models, Molecular | - |
dc.title | Crystal structure of PilF: functional implication in the type 4 pilus biogenesis in Pseudomonas aeruginosa | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김경곤 | - |
dc.contributor.AlternativeAuthor | 오종길 | - |
dc.contributor.AlternativeAuthor | 한도현 | - |
dc.contributor.AlternativeAuthor | 김은경 | - |
dc.contributor.AlternativeAuthor | 이병일 | - |
dc.contributor.AlternativeAuthor | 김영수 | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.12.108 | - |
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