Atopy May Be an Important Determinant of Subepithelial Fibrosis in Subjects with Asymptomatic Airway Hyperresponsiveness

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Sohn, Seong-Wook; Chang, Yoon-Seok; Lee, Hye-Seung; Chung, Doo-Hyun; Lee, Choon-Taek; Kim, Young-Hwan; Kim, Yoon-Keun; Min, Kyung-Up; Kim, You-Young; Cho, Sang-Heon
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대한의학회 = Korean Academy of Medical Science
J Korean Med Sci 2008; 23: 390-6
Asymptomatic Airway Hyperresponsiveness; Atopy; Airway Remodeling; Reticular Basement Membrane; Subepithelial Layer Thickness
The bronchial pathology of asymptomatic airway hyperreponsiveness (AHR) subjects is not well understood, and the role of atopy in the development of airway remodeling is unclear. The aim of this study was to evaluate whether atopy is associated with airway remodeling in asymptomatic AHR subjects. Five groups, i.e., atopic or non-atopic subjects with asymptomatic AHR, atopic or non-atopic healthy controls, and subjects with mild atopic asthma, were evaluated by bronchoscopic biopsy. By electron microscopy, mean reticular basement membrane (RBM) thicknesses were 4.3+/-1.7 micrometer, 3.4+/-1.8 micrometer, 2.5+/-1.5 micrometer, 2.6+/-1.1 micrometer, and 2.3+/-1.2 micrometer in the mild atopic asthma, atopic and non-atopic asymptomatic AHR, atopic and nonatopic control groups, respectively (p=0.002). RBM thicknesses were significantly higher in the mild atopic asthma group and in the atopic asymptomatic AHR group than in the other three groups (p=0.048). No significant difference in RBM thickness was observed between the atopic asymptomatic AHR group and the mild atopic asthma group (p>0.05), nor between non-atopic asymptomatic AHR group and the two control groups (p>0.05). By light microscopy, subepithelial layer thicknesses between the groups showed the same results. These findings suggest that RBM thickening occurs in subjects with atopic asymptomatic AHR, and that atopy plays an important role in airway remodeling.
1011-8934 (print)1598-6357 (online)
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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