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Histological and Immunohistochemical Evaluation of Ductal Carcinoma In Situ Co-Existing with Triple-Negative Carcinoma of the Breast
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seol, Hyesil | - |
dc.contributor.author | Ko, Hyoungsuk | - |
dc.contributor.author | Park, In Ae | - |
dc.date.accessioned | 2009-05-28 | - |
dc.date.available | 2009-05-28 | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Korean J Pathol. 2008;42:373-80 | en |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | http://www.pathology.or.kr/04_JOURN/view.asp?jid=20080373 | - |
dc.identifier.uri | http://www.pathology.or.kr | - |
dc.identifier.uri | https://hdl.handle.net/10371/3991 | - |
dc.description.abstract | BACKGROUND: Triple-negative breast carcinomas (TNBCs) are associated with high-grade histological tumor and a poor clinical outcome. In this study, we evaluated the histology and immunohistochemical features of DCIS co-existing with TNBC to determine the characteristics of the precursor lesions of TNBC. METHODS: Among the 1,610 cases of breast carcinoma, we selected the TNBCs with DCIS (n=196), and compared the pathological and immunohistochemical findings of the DCIS with those of the invasive carcinoma areas. RESULTS: Among the 1,610 breast carcinomas, the TNBCs accounted for 330 cases (20.5%) and there were 196 cases with DCIS. The TN-DCIS cases exhibited high nuclear (94.5%) and histological (94.5%) grades, comedo-necrosis (68.9%) and a small extent of the DCIS-involved area. Immunohistochemically, a p53 expression was present in 48.4% of the TN-DCIS cases and a high Ki-67 index was present in 31.5%. The same TN immunohistochemical profiles as the carcinoma were detected in 109 of the 124 (87.9%) cases, but different profiles were observed in 15 of the 124 (12.1%) cases. The 15 discordant cases were associated with a low histological grade (p=0.037), low p53-positivity (p=0.006) and a low Ki-67 index (p=0.026), as compared to the invasive carcinomas. CONCLUSIONS: The results of this study suggest that TN DCIS is a highly probable, but not obligate, precursor lesion of TNBC. | en |
dc.language.iso | en | en |
dc.publisher | The Korean Society of Pathology = 대한병리학회 | en |
dc.subject | Breast | en |
dc.subject | Noninfiltrating intraductal carcinoma | en |
dc.subject | Immunohistochemistry | en |
dc.title | Histological and Immunohistochemical Evaluation of Ductal Carcinoma In Situ Co-Existing with Triple-Negative Carcinoma of the Breast | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 설혜실 | - |
dc.contributor.AlternativeAuthor | 고형숙 | - |
dc.contributor.AlternativeAuthor | 박인애 | - |
dc.citation.journaltitle | The Korean Journal of Pathology (KJP) = 대한병리학회지 | - |
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