Browse

Hereditary nonpolyposis colorectal cancer in endometrial cancer patients

Cited 20 time in Web of Science Cited 19 time in Scopus
Authors
Yoon, Sang Nam; Ku, Ja-Lok; Shin, Young-Kyoung; Kim, Kyung-Hee; Choi, Jin-Sung; Jang, Eun-Ja; Park, Hyoung-Chul; Kim, Duck-Woo; Kim, Min A; Kim, Woo Ho; Lee, Taek Sang; Kim, Jae Weon; Park, Noh-Hyun; Song, Yong-Sang; Kang, Soon-Beom; Lee, Hyo-Pyo
Issue Date
2007-10-31
Publisher
Wiley-Blackwell
Citation
Int J Cancer 2007;122:1077-81
Keywords
endometrial cancerhereditary nonpolyposis colorectal cancer (HNPCC)microsatellite instability (MSI)mismatch repair gene (MMR)MLH1MSH2MSH6
Abstract
Endometrial cancer is the second most common cancer in hereditary nonpolyposis colorectal cancer (HNPCC). It has often been overlooked to explore the possibility of HNPCC in endometrial cancer patients. Our study was to investigate how many HNPCC patients existed among endometrial cancer patients. Among patients who underwent hysterectomy for endometrial cancer at Seoul National University Hospital from 1996 to 2004, 113 patients were included, whose family history and clinical data could be obtained and tumor specimens were available for microsatellite instability (MSI) testing and immunohistochemical (IHC) staining of MLH1, MSH2 and MSH6 proteins. There were 4 (3.5%) clinical HNPCC patients fulfilling the Amsterdam criteria II, and 2 (2/4, 50%) of them carried MSH2 germline mutations. There were also 8 (7.1%) suspected HNPCC (s-HNPCC) patients fulfilling the revised criteria for s-HNPCC, and one (1/8, 12.5%) of them revealed MLH1 germline mutation. In 101 patients, who were not clinical HNPCC or s-HNPCC, 11 patients showed both MSI-high and loss of expression of MLH1, MSH2 or MSH6 proteins, and 2 (2/11, 18.2%) of them showed MSH6 germline mutations. In 113 patients with endometrial cancer, we could find 5 (4.4%) HNPCC patients with MMR germline mutation and 2 (1.8%) clinical HNPCC patients without identified MMR gene mutation. Family history was critical in detecting 3 HNPCC patients with MMR germline mutation, and MSI testing with IHC staining for MLH1, MSH2 and MSH6 proteins was needed in the diagnosis of 2 HNPCC patients who were not clinical HNPCC or s-HNPCC, especially for MSH6 germline mutation.
ISSN
0020-7136 (print)
1097-0215 (online)
Language
English
URI
http://hdl.handle.net/10371/4231
DOI
https://doi.org/10.1002/ijc.22986

https://doi.org/10.1002/ijc.22986
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse