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Common promoter polymorphism in monocyte differentiation antigen CD14 is associated with serum triglyceride levels and body mass index in non-diabetic individuals
DC Field | Value | Language |
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dc.contributor.author | Shin, H D | - |
dc.contributor.author | Park, K S | - |
dc.contributor.author | Park, B L | - |
dc.contributor.author | Cheong, H S | - |
dc.contributor.author | Cho, Y M | - |
dc.contributor.author | Lee, H K | - |
dc.contributor.author | Lee, J-Y | - |
dc.contributor.author | Lee, J-K | - |
dc.contributor.author | Kim, H T | - |
dc.contributor.author | Han, B G | - |
dc.contributor.author | Kim, J W | - |
dc.contributor.author | Koh, I | - |
dc.contributor.author | Kim, Y J | - |
dc.contributor.author | Oh, B | - |
dc.contributor.author | Kimm, K | - |
dc.contributor.author | Park, C | - |
dc.date.accessioned | 2010-01-25T13:59:55Z | - |
dc.date.available | 2010-01-25T13:59:55Z | - |
dc.date.issued | 2006-01-18 | - |
dc.identifier.citation | Diabet Med. 2006 Jan;23(1):72-6. | en |
dc.identifier.issn | 0742-3071 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16409569 | - |
dc.identifier.uri | https://hdl.handle.net/10371/44043 | - |
dc.description.abstract | AIMS: Growing evidence supports the hypothesis that chronic low-grade inflammation related to innate immunity may play an important role in the pathophysiology of Type 2 diabetes mellitus (T2DM). The monocyte differentiation antigen CD14 gene (CD14) acts as the receptor for lipopolysaccharide (LPS) and augments monocyte/macrophage inflammatory responses. METHODS: We have sequenced the gene, including all exons, exon/intron boundaries, and the -1.5 kb of the 5' flanking region. Two common loci (minor allele frequency > 0.05) were genotyped in 775 T2DM patients and 316 control subjects recruited in the Korean T2DM Study. RESULTS: Eight polymorphisms, including four non-synonymous forms, were identified in CD14. No polymorphisms were found in association with T2DM. However, one common promoter SNP (-260T>C) was significantly associated with both the serum triglyceride level (TG) and body mass index (BMI) in non-diabetic control subjects. Individuals who carried the minor allele (C) had higher TG levels (1.65 +/- 0.81 vs. 1.46 +/- 0.80 mmol/l; P = 0.0007) and BMI (23.96 +/- 3.00 vs. 23.28 +/- 3.22 kg/m(2); P = 0.04) as compared with subjects carrying T/T genotypes. CONCLUSION: Our data suggest that lipid metabolism and obesity, important pathophysiological elements of T2DM and the metabolic syndrome, are regulated by complex mechanisms that include the CD14 gene polymorphism-mediated genetic propensity to non-specific inflammatory responses. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Antigens, CD14/*genetics | en |
dc.subject | Base Sequence | en |
dc.subject | Diabetes Mellitus, Type 2/genetics | en |
dc.subject | Exons/genetics | en |
dc.subject | Female | en |
dc.subject | Gene Frequency/genetics | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Introns/genetics | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Genetic/*genetics | en |
dc.subject | Polymorphism, Single Nucleotide/genetics | en |
dc.subject | Promoter Regions, Genetic/*genetics | en |
dc.subject | Triglycerides/*blood | en |
dc.subject | Body Mass Index | - |
dc.title | Common promoter polymorphism in monocyte differentiation antigen CD14 is associated with serum triglyceride levels and body mass index in non-diabetic individuals | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1464-5491.2005.01732.x | - |
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