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Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia
DC Field | Value | Language |
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dc.contributor.author | Ryu, J-H | - |
dc.contributor.author | Kang, M-H | - |
dc.contributor.author | Park, K-S | - |
dc.contributor.author | Do, S-H | - |
dc.date.accessioned | 2010-01-28 | - |
dc.date.available | 2010-01-28 | - |
dc.date.issued | 2008-02-16 | - |
dc.identifier.citation | Br J Anaesth. 2008 Mar;100(3):397-403. | en |
dc.identifier.issn | 1471-6771 (Electronic) | - |
dc.identifier.issn | 1471-6771 (Linking) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18276652 | - |
dc.identifier.uri | http://bja.oxfordjournals.org/cgi/reprint/100/3/397.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/45963 | - |
dc.description.abstract | BACKGROUND: This randomized, double-blind, prospective study was undertaken to evaluate the effects of magnesium sulphate on anaesthetic requirements and postoperative analgesia in patients undergoing total i.v. anaesthesia (TIVA). METHODS: Fifty patients who underwent gynaecological surgery were randomly divided into two groups. Before induction of anaesthesia, the magnesium group (Group M) received magnesium sulphate 50 mg kg(-1) i.v. as a bolus and then 15 mg kg(-1) h(-1) i.v. by continuous infusion. The control group (Group S) received the same amount of isotonic saline. TIVA (propofol+remifentanil) was administered under bispectral index monitoring during anaesthesia induction and maintenance. Rocuronium was administered before orotracheal intubation and during surgery when the train-of-four count was 2 or more. After operation, patient-controlled analgesia with a solution of ketorolac and morphine was used and the consumption of this solution was recorded. Pain scores at rest and upon movement were evaluated 30 min, 4, 24, and 48 h after surgery. RESULTS: Patients in Group M required less rocuronium than those in Group S [mean (SD) 0.44 (0.09) vs 0.35 (0.07) microg kg(-1) min(-1), P<0.05]. The total amounts of propofol and remifentanil administered were similar in the two groups. Postoperative pain scores, cumulative analgesic consumption, and shivering incidents were significantly lower in Group M (P<0.05). Mean arterial pressure just after intubation and during the immediate postoperative period was also significantly lower in Group M (P<0.05). CONCLUSIONS: I.v. magnesium sulphate during TIVA reduced rocuronium requirement and improved the quality of postoperative analgesia. | en |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | en |
dc.subject | Adult | en |
dc.subject | Analgesia, Patient-Controlled/methods | en |
dc.subject | Analgesics/*pharmacology | en |
dc.subject | Anesthesia, Intravenous | en |
dc.subject | Anesthetics, Intravenous/*administration & dosage | en |
dc.subject | Double-Blind Method | en |
dc.subject | Drug Administration Schedule | en |
dc.subject | Female | en |
dc.subject | Gynecologic Surgical Procedures | en |
dc.subject | Humans | en |
dc.subject | Magnesium Sulfate/*pharmacology | en |
dc.subject | Middle Aged | en |
dc.subject | Pain Measurement/methods | en |
dc.subject | Pain, Postoperative/*prevention & control | en |
dc.subject | Piperidines/administration & dosage | en |
dc.subject | Propofol/administration & dosage | en |
dc.title | Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia | en |
dc.type | Article | en |
dc.identifier.doi | 10.1093/bja/aem407 | - |
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