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Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells

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Authors
Gil, Jung-Eun; Woo, Dong-Hun; Shim, Joong-Hyun; Kim, Sung-Eun; You, Hyun-Ju; Park, Sung-Hye; Paek, Sun Ha; Kim, Suel-Kee; Kim, Jong-Hoon
Issue Date
2009-01-24
Publisher
the Federation of European Biochemical Societies; Elsevier
Citation
FEBS Lett. 583, 561-567
Keywords
Human embryonic stem cells; Oligodendrocytes; Vitronectin; Differentiation
Abstract
We demonstrate enhanced differentiation of oligodendrocytes during neurogenesis of human embryonic stem cells (hESCs) using an extracellular matrix protein, vitronectin (VN). We show that VN is expressed in the ventral part of the developing human spinal cord. Combined treatment of retinoic acid, sonic hedgehog, and noggin in the presence of VN allows hESCs to differentiate into O4-positive oligodendrocytes. Particularly, VN profoundly promotes the derivation of oligodendrocyte progenitors that proliferate and differentiate into oligodendrocytes in response to mitogenic and survival factors. These results support the beneficial effect of VN on oligodendrocytic differentiation of hESCs.
ISSN
0014-5793 (print)1873-3468 (online)
Language
English
URI
http://hdl.handle.net/10371/4613
DOI
https://doi.org/10.1016/j.febslet.2008.12.061
https://doi.org/10.1016/j.febslet.2008.12.061
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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